Title:
EFFICACIOUS MRNA VACCINES
Document Type and Number:
WIPO Patent Application WO/2019/036670
Kind Code:
A3
Abstract:
High quality vaccines are identified and formulated based on a threshold differential T-cell activation potential. The vaccines are mRNA vaccines formulated in a carrier, wherein the mRNA encodes an antigen.
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Inventors:
HOGE STEPHEN (US)
CIARAMELLA GIUSEPPE (US)
CIARAMELLA GIUSEPPE (US)
Application Number:
PCT/US2018/046974
Publication Date:
May 23, 2019
Filing Date:
August 17, 2018
Export Citation:
Assignee:
MODERNATX INC (US)
International Classes:
A61K9/51; A61K31/7088; A61K39/145; A61K47/69; A61P31/16; G01N33/50
Domestic Patent References:
| WO2015164674A1 | 2015-10-29 | |||
| WO2016176330A1 | 2016-11-03 | |||
| WO2018089851A2 | 2018-05-17 | |||
| WO2018170245A1 | 2018-09-20 | |||
| WO2018078053A1 | 2018-05-03 | |||
| WO2018081638A1 | 2018-05-03 | |||
| WO2017191258A1 | 2017-11-09 |
Other References:
BENTEBIBEL S.-E. ET AL: "ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination", SCIENTIFIC REPORTS, vol. 6, 27 May 2016 (2016-05-27), pages 26494, XP055611535, Retrieved from the Internet DOI: 10.1038/srep26494
LIANG F. ET AL: "Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 393, 7 June 2017 (2017-06-07), pages eaal2094, XP055611537, Retrieved from the Internet DOI: 10.1126/scitranslmed.aal2094
WANG C. ET AL: "Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant forpromoting long-term immunological memory", VACCINE, vol. 32, no. 42, 22 September 2014 (2014-09-22), pages 5475 - 5483, XP055611539, DOI: 10.1016/j.vaccine.2014.07.081
HEITHOFF D.M. ET AL: "Conditions that diminish Myeloid-Derived Suppressor Cell activities stimulate cross-protective immunity", INFECTION AND IMMUNITY, vol. 76, no. 11, 1 November 2008 (2008-11-01), pages 5191 - 5199, XP055611543, DOI: 10.1128/IAI.00759-08
LIANG F. ET AL: "Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 393, 7 June 2017 (2017-06-07), pages eaal2094, XP055611537, Retrieved from the Internet
WANG C. ET AL: "Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant forpromoting long-term immunological memory", VACCINE, vol. 32, no. 42, 22 September 2014 (2014-09-22), pages 5475 - 5483, XP055611539, DOI: 10.1016/j.vaccine.2014.07.081
HEITHOFF D.M. ET AL: "Conditions that diminish Myeloid-Derived Suppressor Cell activities stimulate cross-protective immunity", INFECTION AND IMMUNITY, vol. 76, no. 11, 1 November 2008 (2008-11-01), pages 5191 - 5199, XP055611543, DOI: 10.1128/IAI.00759-08
Attorney, Agent or Firm:
LOCKHART, Helen C. (US)
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