Title:
Eg5 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/174745
Kind Code:
A1
Abstract:
Compared to a traditional Eg5 (KSP: kinesin spindle protein) inhibitor, this water-soluble polycyclic compound or a pharmacologically acceptable salt thereof has a greater solubility in an aqueous solvent and has Eg5 inhibitory activity that is equivalent to or greater than that of the traditional Eg5 inhibitor. Furthermore, due to these properties, the present invention has a remarkable growth inhibiting activity against various cancer cells and is very effective for the treatment of cancer, etc.
Inventors:
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
TAKEUCHI TOMOKI (JP)
ASAI AKIRA (JP)
SAWADA JUNICHI (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
TAKEUCHI TOMOKI (JP)
ASAI AKIRA (JP)
SAWADA JUNICHI (JP)
Application Number:
PCT/JP2014/000982
Publication Date:
October 30, 2014
Filing Date:
February 25, 2014
Export Citation:
Assignee:
UNIV KYOTO (JP)
GEN INC ASS PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP)
GEN INC ASS PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP)
International Classes:
C07C275/40; A61K31/136; A61K31/17; A61K31/423; A61K31/428; A61K31/4704; A61K31/4709; A61K31/497; A61K31/506; A61K31/538; A61P35/00; A61P43/00; C07C211/56; C07D209/40; C07D215/20; C07D215/36; C07D215/38; C07D223/16; C07D263/58; C07D265/36; C07D277/68; C07D279/16; C07D401/12; C07D417/12
Domestic Patent References:
| WO2010073719A1 | 2010-07-01 | |||
| WO2000015604A1 | 2000-03-23 | |||
| WO2012115479A2 | 2012-08-30 | |||
| WO2010138820A2 | 2010-12-02 | |||
| WO2012022408A1 | 2012-02-23 |
Foreign References:
| JP2012530129A | 2012-11-29 | |||
| JP2010508268A | 2010-03-18 | |||
| CN102675280A | 2012-09-19 | |||
| JPH01308265A | 1989-12-12 | |||
| JP2007537230A | 2007-12-20 | |||
| JP2007537234A | 2007-12-20 | |||
| JPS63280078A | 1988-11-17 | |||
| JP2010513335A | 2010-04-30 |
Other References:
YOUJI HUAXUE, vol. 27, no. 12, 2007, pages 1567 - 1572
INDIAN JOURNAL OF CHEMISTRY. SECTION B: ORGANIC INCLUDING MEDICINAL, vol. 20 B, no. 4, 1981, pages 308 - 310
INDIAN JOURNAL OF CHEMISTRY. SECTION B: ORGANIC INCLUDING MEDICINAL, vol. 20 B, no. 4, 1981, pages 308 - 310
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Masaki Hirota (JP)
Masaki Hirota (JP)
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