Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
Eg5 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/174745
Kind Code:
A1
Abstract:
Compared to a traditional Eg5 (KSP: kinesin spindle protein) inhibitor, this water-soluble polycyclic compound or a pharmacologically acceptable salt thereof has a greater solubility in an aqueous solvent and has Eg5 inhibitory activity that is equivalent to or greater than that of the traditional Eg5 inhibitor. Furthermore, due to these properties, the present invention has a remarkable growth inhibiting activity against various cancer cells and is very effective for the treatment of cancer, etc.

Inventors:
FUJII, Nobutaka (Kyoto University 46-29, Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
OHNO, Hiroaki (Kyoto University 46-29, Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
OISHI, Shinya (Kyoto University 46-29, Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
TAKEUCHI, Tomoki (Kyoto University 46-29, Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
ASAI, Akira (52-1 Yada, Suruga-ku, Shizuoka-sh, Shizuoka 26, 〒4228526, JP)
SAWADA, Junichi (52-1 Yada, Suruga-ku, Shizuoka-sh, Shizuoka 26, 〒4228526, JP)
Application Number:
JP2014/000982
Publication Date:
October 30, 2014
Filing Date:
February 25, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KYOTO UNIVERSITY (36-1, Yoshida-honmachi Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (7-25, Bunkyo-cho 1-chome Mishima-sh, Shizuoka 33, 〒4110033, JP)
International Classes:
C07C275/40; A61K31/136; A61K31/17; A61K31/423; A61K31/428; A61K31/4704; A61K31/4709; A61K31/497; A61K31/506; A61K31/538; A61P35/00; A61P43/00; C07C211/56; C07D209/40; C07D215/20; C07D215/36; C07D215/38; C07D223/16; C07D263/58; C07D265/36; C07D277/68; C07D279/16; C07D401/12; C07D417/12
Domestic Patent References:
WO2010073719A1
WO2000015604A1
WO2012115479A2
WO2010138820A2
WO2012022408A1
Foreign References:
JP2012530129A
JP2010508268A
CN102675280A
JPH01308265A
JP2007537230A
JP2007537234A
JPS63280078A
JP2010513335A
Other References:
YOUJI HUAXUE vol. 27, no. 12, 2007, pages 1567 - 1572
INDIAN JOURNAL OF CHEMISTRY. SECTION B: ORGANIC INCLUDING MEDICINAL vol. 20 B, no. 4, 1981, pages 308 - 310
Attorney, Agent or Firm:
HIROTA, Masanori (6th Fl. Address Bldg. 2-2-19, Akasaka Minato-k, Tokyo 52, 〒1070052, JP)
Download PDF: