EGFR SINGLE-DOMAIN ANTIBODY CART FOR TREATING TUMOR AND APPLICATION THEREOF

Title:

EGFR SINGLE-DOMAIN ANTIBODY CART FOR TREATING TUMOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/014891

Kind Code:

A1

Abstract:

Provided is a CART cell modified by an EGFR single-domain antibody, wherein the CART cell can be used to treat a tumor. Also provided are a humanized EGFR single-domain antibody gene and a single-domain antibody encoded thereby, an EGFR CAR gene and an EGFR CAR chimeric antigen receptor encoded thereby, and a lentiviral vector Pre-Lenti-EF1-EGFR CAR containing the EGFR CAR gene.

Inventors:

ZHANG JISHUAI (CN)
LI SHENGHUA (CN)
LI HONGJIAN (CN)
ZHAO YANGYANG (CN)
YU XIANG (CN)
ZHENG MENGTAO (CN)
HE YU (CN)
HE PENGHUA (CN)

Application Number:

PCT/CN2017/093652

Publication Date:

January 24, 2019

Filing Date:

July 20, 2017

Export Citation:

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Assignee:

PREGENE BIOPHARMA COMPANY SHENZHEN (CN)

International Classes:

C12N5/10; A61K35/17; A61P35/00; C07K19/00; C12N15/62; C12N15/66; C12N15/86

Domestic Patent References:

WO2013123061A1

2013-08-22

Foreign References:

CN105384825A	2016-03-09
CN106636003A	2017-05-10
CN101321784A	2008-12-10

Other References:

ZHANG, MANZE ET AL.: "Research Progress of Chimeric Antigen Receptor-Engineered T Cells in Solid Tumors Therapy", IMMUNOLOGICAL JOURNAL, vol. 33, no. 3, 31 March 2017 (2017-03-31), pages 251 - 257, ISSN: 1000-8861
BELL, A. ET AL.: "Differential Tumor-Targeting Abilities of Three Single-domain Antibody Formats", CANCER LETTERS, vol. 289, 31 December 2010 (2010-12-31), pages 81 - 90, XP026897079, ISSN: 0304-3835

Attorney, Agent or Firm:

JEEKAI & PARTNERS (CN)

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