Title:
EGG ALLERGY PREVENTING AGENT OR THE LIKE, AND FOOD COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2021/125303
Kind Code:
A1
Abstract:
The present invention provides a highly effective and safe means capable of preventing or treating egg allergy in infants. According to the present invention, an oral immunotolerant or a food composition for preventing or treating egg allergy contains a degradation product of egg white heat-denatured by aspartic protease (for example, pepsin) or metalloprotease (for example, thermolysin).
Inventors:
AYABE AYAKO (JP)
HASEGAWA TAKANORI (JP)
MATSUMOTO KENJI (JP)
MORITA HIDEAKI (JP)
HASEGAWA TAKANORI (JP)
MATSUMOTO KENJI (JP)
MORITA HIDEAKI (JP)
Application Number:
PCT/JP2020/047305
Publication Date:
June 24, 2021
Filing Date:
December 18, 2020
Export Citation:
Assignee:
NAT CT CHILD HEALTH & DEV (JP)
NH FOODS LTD (JP)
NH FOODS LTD (JP)
International Classes:
A61K35/57; A23L33/18; A61K38/01; A61P37/06; A61P37/08
Foreign References:
| JP2010504278W |
Other References:
LOZANO-OJALVO, D. ET AL.: "Hydrolysed ovalbumin offers more effective preventive and therapeutic protection against egg allergy than the intact protein", CLINICAL & EXPERIMENTAL ALLERGY, vol. 47, no. 10, 1 October 2017 (2017-10-01), pages 1342 - 1354, XP055836233, ISSN: 0954-7894
MATSUDA, T. ET AL.: "Reduction of ovomucoid immunogenic activity on peptic fragmentation and heat denaturation", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 49, no. 7, 1985, pages 2237 - 2241, XP001062263, ISSN: 0002-1369
HILDEBRANDT, S. ET AL.: "In Vitro Determination of the Allergenic Potential of Technologically Altered Hen's Egg", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 56, no. 5, 2008, pages 1727 - 1733, XP055445633, ISSN: 0021-8561, DOI: 10.1021/jf0725981
JIMENEZ-SAIZ, R. ET AL.: "Human Immunoglobul in E (IgE) Binding to Heated and Glycated Ovalbumin and Ovomucoid before and after in Vitro Digestion", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 59, no. 18, 28 September 2011 (2011-09-28), pages 10044 - 10051, XP055836234, ISSN: 0021-8561
BESLER, M ET AL.: "Identification of IgE-binding peptides derived from chemical and enzymatic cleavage of Ovomucoid (Gal d 1)", INTERNET SYMPOSIUM ON FOOD ALLERGENS, vol. 1, no. 1, 1999, pages 1 - 12, XP055836259, ISSN: 1437-0573
UNNO, HIROTOSHI ET AL.: "IL -33 in allergic diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 252, no. 12, pages 1233 - 1238
FLOHR ET AL., J INVEST DERMATOL, vol. 134, no. 2, 18 July 2013 (2013-07-18), pages 345 - 350
KUBO ET AL., J CLIN INVEST., vol. 122, no. 2, 1 February 2012 (2012-02-01), pages 440 - 7
KITAGAWA H ET AL., ALLERGOLOGY INT., 2019
FUKUIE ET AL., RECOMMENDATIONS ON PREVENTION OF DEVELOPMENT OF HEN'S EGG ALLERGY, 2017
NATSUME ET AL., LANCET, vol. 389, no. 10066, 9 December 2016 (2016-12-09), pages 276 - 286
DU TOIT ET AL., J ALLERGY CLIN IMMUNOL., vol. 141, no. 4, 31 October 2017 (2017-10-31), pages 1343 - 1353
MATSUMOTO ET AL., J ALLERGY CLIN IMMUNOL., vol. 141, no. 6, 6 March 2018 (2018-03-06), pages 1997 - 2001
IKEMATSU ET AL., JAPANESE JOURNAL OF ALLERGOLOGY, vol. 55, no. 5, 2006, pages 533 - 541
LOZANO-OJALVO ET AL., CLIN EXP ALLERGY, vol. 47, no. 10, 2017, pages 1342 - 1354
See also references of EP 4079315A4
MATSUDA, T. ET AL.: "Reduction of ovomucoid immunogenic activity on peptic fragmentation and heat denaturation", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 49, no. 7, 1985, pages 2237 - 2241, XP001062263, ISSN: 0002-1369
HILDEBRANDT, S. ET AL.: "In Vitro Determination of the Allergenic Potential of Technologically Altered Hen's Egg", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 56, no. 5, 2008, pages 1727 - 1733, XP055445633, ISSN: 0021-8561, DOI: 10.1021/jf0725981
JIMENEZ-SAIZ, R. ET AL.: "Human Immunoglobul in E (IgE) Binding to Heated and Glycated Ovalbumin and Ovomucoid before and after in Vitro Digestion", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 59, no. 18, 28 September 2011 (2011-09-28), pages 10044 - 10051, XP055836234, ISSN: 0021-8561
BESLER, M ET AL.: "Identification of IgE-binding peptides derived from chemical and enzymatic cleavage of Ovomucoid (Gal d 1)", INTERNET SYMPOSIUM ON FOOD ALLERGENS, vol. 1, no. 1, 1999, pages 1 - 12, XP055836259, ISSN: 1437-0573
UNNO, HIROTOSHI ET AL.: "IL -33 in allergic diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 252, no. 12, pages 1233 - 1238
FLOHR ET AL., J INVEST DERMATOL, vol. 134, no. 2, 18 July 2013 (2013-07-18), pages 345 - 350
KUBO ET AL., J CLIN INVEST., vol. 122, no. 2, 1 February 2012 (2012-02-01), pages 440 - 7
KITAGAWA H ET AL., ALLERGOLOGY INT., 2019
FUKUIE ET AL., RECOMMENDATIONS ON PREVENTION OF DEVELOPMENT OF HEN'S EGG ALLERGY, 2017
NATSUME ET AL., LANCET, vol. 389, no. 10066, 9 December 2016 (2016-12-09), pages 276 - 286
DU TOIT ET AL., J ALLERGY CLIN IMMUNOL., vol. 141, no. 4, 31 October 2017 (2017-10-31), pages 1343 - 1353
MATSUMOTO ET AL., J ALLERGY CLIN IMMUNOL., vol. 141, no. 6, 6 March 2018 (2018-03-06), pages 1997 - 2001
IKEMATSU ET AL., JAPANESE JOURNAL OF ALLERGOLOGY, vol. 55, no. 5, 2006, pages 533 - 541
LOZANO-OJALVO ET AL., CLIN EXP ALLERGY, vol. 47, no. 10, 2017, pages 1342 - 1354
See also references of EP 4079315A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
Download PDF: