Title:
EHRLICHIA CANIS GENES AND VACCINES
Document Type and Number:
WIPO Patent Application WO2003089571
Kind Code:
A3
Abstract:
This invention provides the sequence of 5,299 nucleotides from the E.canis genome. There are four proteins, ProA, ProB, MmpA, and a cytochrome oxidase homolog, as well as a partial lipoprotein signal peptidase homolog at the carboxy terminus, coded for in this cloned fragment. The antigenic properties of these proteins allow them to be used to create a vaccine. An embodiment of this invention includes the creation of a DNA vaccine, a recombinant vaccine, and a T cell epitope vaccine. Another embodiment of this invention includes the use of serological diagnosis techniques.
Inventors:
CHANG YUNG-FU (US)
Application Number:
PCT/US2002/035136
Publication Date:
June 10, 2004
Filing Date:
November 01, 2002
Export Citation:
Assignee:
CORNELL RES FOUNDATION INC (US)
CHANG YUNG-FU (US)
CHANG YUNG-FU (US)
International Classes:
G01N33/50; A61K38/00; A61K38/21; A61K39/02; A61K39/39; A61K48/00; A61P31/04; A61P37/04; C07K14/29; C07K14/47; C12N1/21; C12N9/02; C12N9/52; C12N15/09; C12N15/31; C12P21/02; G01N33/15; G01N33/53; G01N33/566; A61K39/00; (IPC1-7): A61K31/70; C07H21/02
Domestic Patent References:
| WO2001007625A2 | 2001-02-01 |
Other References:
DATABASE GENBANK [online] 22 February 2001 (2001-02-22), CHANG, Y.F., XP002975550, accession no. NCBI Database accession no. AX077837
OGASWARA ET AL.: "A strategy for making synthetic peptide vaccines", PNAS, vol. 89, October 1992 (1992-10-01), pages 8995 - 8999, XP000306532
CHANG ET AL.: "Specific Amplification of Ehrlichia platys DNA from blood specimens by two-step PCR", J. CLIN. MICRO., vol. 34, no. 12, December 1996 (1996-12-01), pages 3142 - 3146, XP002975551
OGASWARA ET AL.: "A strategy for making synthetic peptide vaccines", PNAS, vol. 89, October 1992 (1992-10-01), pages 8995 - 8999, XP000306532
CHANG ET AL.: "Specific Amplification of Ehrlichia platys DNA from blood specimens by two-step PCR", J. CLIN. MICRO., vol. 34, no. 12, December 1996 (1996-12-01), pages 3142 - 3146, XP002975551
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