Title:
ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS
Document Type and Number:
WIPO Patent Application WO2005026178
Kind Code:
A3
Abstract:
The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
Inventors:
DIEBOLD ERIC R (US)
GHOSHAL MITALI (US)
DENG DAVID Z (US)
TSAI JANE SHIOW-CHUAN (US)
GHOSHAL MITALI (US)
DENG DAVID Z (US)
TSAI JANE SHIOW-CHUAN (US)
Application Number:
PCT/US2004/021187
Publication Date:
November 24, 2005
Filing Date:
July 01, 2004
Export Citation:
Assignee:
ROCHE DIAGNOSTICS GMBH (DE)
HOFFMANN LA ROCHE (CH)
DIEBOLD ERIC R (US)
GHOSHAL MITALI (US)
DENG DAVID Z (US)
TSAI JANE SHIOW-CHUAN (US)
HOFFMANN LA ROCHE (CH)
DIEBOLD ERIC R (US)
GHOSHAL MITALI (US)
DENG DAVID Z (US)
TSAI JANE SHIOW-CHUAN (US)
International Classes:
C07F15/00; G01N27/30; G01N27/48; G01N33/53; G01N33/532; G01N33/543; G01N33/58; (IPC1-7): C07F15/00; G01N33/543; G01N33/58; G01N33/532
Domestic Patent References:
| WO1996025514A1 | 1996-08-22 | |||
| WO2000072019A2 | 2000-11-30 | |||
| WO1993022678A2 | 1993-11-11 | |||
| WO2003044511A2 | 2003-05-30 |
Foreign References:
| US5589326A | 1996-12-31 | |||
| US20030096997A1 | 2003-05-22 | |||
| US6262264B1 | 2001-07-17 | |||
| US6352824B1 | 2002-03-05 | |||
| US5958791A | 1999-09-28 | |||
| US6294062B1 | 2001-09-25 | |||
| US5874046A | 1999-02-23 |
Other References:
NAKABAYASHI Y ET AL: "Evaluation of osmium(II) complexes as mediators accessible for biosensors", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 66, no. 1-3, 25 July 2000 (2000-07-25), pages 128 - 130, XP004209963, ISSN: 0925-4005
TANSIL ET AL.: "Direct Detection of DNA with an Electroctalytic Threading Intercalator", ANAL. CHEM., vol. 77, 12 March 2004 (2004-03-12), pages 126 - 134, XP002322466
CSÖREGI E ET AL: "Design, characterization, and one-point in vivo calibration of a subcutaneously implanted glucose electrode", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 19, 1 October 1994 (1994-10-01), pages 3131 - 3138, XP002083851, ISSN: 0003-2700
JACOBS P ET AL: "Design optimisation of planar electrolytic conductivity sensorsS", MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING, vol. 33, no. 6, 1 November 1995 (1995-11-01), pages 802 - 810, XP000540713, ISSN: 0140-0118
PAESCHKE M ET AL: "Properties of interdigital electrode arrays with different geometries", ANALYTICA CHIMICA ACTA, vol. 305, no. 1/3, 1995, pages 126 - 136, XP000863505, ISSN: 0003-2670
TANSIL ET AL.: "Direct Detection of DNA with an Electroctalytic Threading Intercalator", ANAL. CHEM., vol. 77, 12 March 2004 (2004-03-12), pages 126 - 134, XP002322466
CSÖREGI E ET AL: "Design, characterization, and one-point in vivo calibration of a subcutaneously implanted glucose electrode", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 19, 1 October 1994 (1994-10-01), pages 3131 - 3138, XP002083851, ISSN: 0003-2700
JACOBS P ET AL: "Design optimisation of planar electrolytic conductivity sensorsS", MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING, vol. 33, no. 6, 1 November 1995 (1995-11-01), pages 802 - 810, XP000540713, ISSN: 0140-0118
PAESCHKE M ET AL: "Properties of interdigital electrode arrays with different geometries", ANALYTICA CHIMICA ACTA, vol. 305, no. 1/3, 1995, pages 126 - 136, XP000863505, ISSN: 0003-2670
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