Title:
ELECTROCHEMICAL APTAMER SENSORS WITH STABLE BLOCKING LAYERS, RAPID ELECTRON TRANSFER AND ROBUST ANTIFOULING PROPERTIES
Document Type and Number:
WIPO Patent Application WO/2023/049328
Kind Code:
A3
Abstract:
The present invention relates to a device for continuous sensing of at least one analyte in a test fluid that is resistant at least one of desorption of a first plurality of molecules, including a plurality of aptamers and a blocking layer, and fouling during use of the device when exposed to temperatures greater than or equal to 30°C for at least 3 days. Another aspect of the invention is a method of providing fouling resistance to an aptamer sensor device wherein the blocking layer and aptamer are resistant to at least one of desorption from the electrode and fouling during use of the aptamer sensor when exposed to temperatures greater than or equal to 30°C for at least 3 days.
Inventors:
HEIKENFELD JASON CHARLES (US)
Application Number:
PCT/US2022/044512
Publication Date:
April 27, 2023
Filing Date:
September 23, 2022
Export Citation:
Assignee:
UNIV CINCINNATI (US)
International Classes:
G01N27/327; C12Q1/26
Domestic Patent References:
| WO2021030517A1 | 2021-02-18 | |||
| WO2017164982A1 | 2017-09-28 |
Foreign References:
| KR20060080097A | 2006-07-07 | |||
| US20190383770A1 | 2019-12-19 | |||
| US20190230766A1 | 2019-07-25 | |||
| US20130307093A1 | 2013-11-21 |
Other References:
SHAVER ALEXANDER, CURTIS SAMUEL D., ARROYO-CURRÁS NETZAHUALCÓYOTL: "Alkanethiol Monolayer End Groups Affect the Long-Term Operational Stability and Signaling of Electrochemical, Aptamer-Based Sensors in Biological Fluids", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 9, 4 March 2020 (2020-03-04), US , pages 11214 - 11223, XP093064762, ISSN: 1944-8244, DOI: 10.1021/acsami.9b22385
ZHAO XIAO-MEI, WILBUR JAMES L, WHITESIDES GEORGE M: "Using Two-Stage Chemical Amplification To Determine the Density of Defects in Self-Assembled Monolayers of Alkanethiolates on Gold", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 13, 26 June 1996 (1996-06-26), US , pages 3257 - 3264, XP093064766, ISSN: 0743-7463, DOI: 10.1021/la960044e
CHAO ZHANG, HAO-NAN LI, YONG DU, MENG-QI MA, ZHI-KANG XU: "CuSO 4 /H 2 O 2 -Triggered Polydopamine/Poly(sulfobetaine methacrylate) Coatings for Antifouling Membrane Surfaces", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 5, 7 February 2017 (2017-02-07), US , pages 1210 - 1216, XP055506573, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b03948
KOO WON-TAE, KIM YOONSEOB, SAVAGATRUP SUCHOL, YOON BORA, JEON INTAK, CHOI SEON-JIN, KIM IL-DOO, SWAGER TIMOTHY M.: "Porous Ion Exchange Polymer Matrix for Ultrasmall Au Nanoparticle-Decorated Carbon Nanotube Chemiresistors", CHEMISTRY OF MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 15, 13 August 2019 (2019-08-13), US , pages 5413 - 5420, XP093064769, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.9b00504
SUAREZ-MARTINEZ, I. ; BITTENCOURT, C. ; KE, X. ; FELTEN, A. ; PIREAUX, J.J. ; GHIJSEN, J. ; DRUBE, W. ; VAN TENDELOO, G. ; EWELS, : "Probing the interaction between gold nanoparticles and oxygen functionalized carbon nanotubes", CARBON, ELSEVIER OXFORD, GB, vol. 47, no. 6, 1 May 2009 (2009-05-01), GB , pages 1549 - 1554, XP026077040, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2009.02.002
CERRUTI MARTA, FISSOLO STEFANO, CARRARO CARLO, RICCIARDI CARLO, MAJUMDAR ARUN, MABOUDIAN ROYA: "Poly(ethylene glycol) Monolayer Formation and Stability on Gold and Silicon Nitride Substrates", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 19, 7 October 2008 (2008-10-07), US , pages 10646 - 10653, XP055951455, ISSN: 0743-7463, DOI: 10.1021/la801357v
ZHAO XIAO-MEI, WILBUR JAMES L, WHITESIDES GEORGE M: "Using Two-Stage Chemical Amplification To Determine the Density of Defects in Self-Assembled Monolayers of Alkanethiolates on Gold", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 13, 26 June 1996 (1996-06-26), US , pages 3257 - 3264, XP093064766, ISSN: 0743-7463, DOI: 10.1021/la960044e
CHAO ZHANG, HAO-NAN LI, YONG DU, MENG-QI MA, ZHI-KANG XU: "CuSO 4 /H 2 O 2 -Triggered Polydopamine/Poly(sulfobetaine methacrylate) Coatings for Antifouling Membrane Surfaces", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 5, 7 February 2017 (2017-02-07), US , pages 1210 - 1216, XP055506573, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b03948
KOO WON-TAE, KIM YOONSEOB, SAVAGATRUP SUCHOL, YOON BORA, JEON INTAK, CHOI SEON-JIN, KIM IL-DOO, SWAGER TIMOTHY M.: "Porous Ion Exchange Polymer Matrix for Ultrasmall Au Nanoparticle-Decorated Carbon Nanotube Chemiresistors", CHEMISTRY OF MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 15, 13 August 2019 (2019-08-13), US , pages 5413 - 5420, XP093064769, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.9b00504
SUAREZ-MARTINEZ, I. ; BITTENCOURT, C. ; KE, X. ; FELTEN, A. ; PIREAUX, J.J. ; GHIJSEN, J. ; DRUBE, W. ; VAN TENDELOO, G. ; EWELS, : "Probing the interaction between gold nanoparticles and oxygen functionalized carbon nanotubes", CARBON, ELSEVIER OXFORD, GB, vol. 47, no. 6, 1 May 2009 (2009-05-01), GB , pages 1549 - 1554, XP026077040, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2009.02.002
CERRUTI MARTA, FISSOLO STEFANO, CARRARO CARLO, RICCIARDI CARLO, MAJUMDAR ARUN, MABOUDIAN ROYA: "Poly(ethylene glycol) Monolayer Formation and Stability on Gold and Silicon Nitride Substrates", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 19, 7 October 2008 (2008-10-07), US , pages 10646 - 10653, XP055951455, ISSN: 0743-7463, DOI: 10.1021/la801357v
Attorney, Agent or Firm:
JEFFERIES, David E. (US)
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