ELECTROCHEMICAL METHODS AND DEVICES FOR USE IN THE DETERMINATION OF HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS

Title:

ELECTROCHEMICAL METHODS AND DEVICES FOR USE IN THE DETERMINATION OF HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS

Document Type and Number:

WIPO Patent Application WO2001057510

Kind Code:

A3

Abstract:

Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physiological sample is introduced into an electrochemical cell having a working and reference electrode. A first electric potential is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second time-current transient is determined. The preliminary concentration of the analyte is then calculated from the first and/or second time-current transient. This preliminary analyte concentration less a background value is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable gamma of the electrochemical cell. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.

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Inventors:

OHARA TIMOTHY J
KERMANI MAHYAR Z

Application Number:

PCT/US2001/002465

Publication Date:

February 21, 2002

Filing Date:

January 25, 2001

Export Citation:

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Assignee:

LIFESCAN INC (US)

International Classes:

A61B5/145; G01N33/483; G01N27/26; G01N27/327; G01N27/416; G01N33/487; G01N33/66; G01N33/96; (IPC1-7): G01N33/487

Domestic Patent References:

WO1999060391A1	1999-11-25
WO1999032881A1	1999-07-01

Foreign References:

US5942102A	1999-08-24
EP0735363A1	1996-10-02
EP0928967A2	1999-07-14

Other References: