Title:
ELECTROLYTE SOLUTION FOR ANALYSIS OF BIOMOLECULE, DEVICE FOR ANALYSIS OF BIOMOLECULE, AND APPARATUS FOR ANALYSIS OF BIOMOLECULE
Document Type and Number:
WIPO Patent Application WO/2018/016117
Kind Code:
A1
Abstract:
A nanopore DNA sequencing method has a problem that if signal changes for signal analysis include a signal change based on a fluctuation of a base current, a signal analysis error occurs. This electrolyte solution for analysis of a biomolecule, containing D2O as a solvent, and/or containing an electrolyte which provides, as cationic species in the solution, Cs and Na, only Na, Na and Li, or only Li, or containing trishydroxyaminomethane, or containing a combination thereof, is used for formation or measurement of a nanopore (see fig. 6).
Inventors:
AKAHORI RENA (JP)
GOTO YUSUKE (JP)
MATSUI KAZUMA (JP)
YOKOI TAKAHIDE (JP)
GOTO YUSUKE (JP)
MATSUI KAZUMA (JP)
YOKOI TAKAHIDE (JP)
Application Number:
PCT/JP2017/008897
Publication Date:
January 25, 2018
Filing Date:
March 07, 2017
Export Citation:
Assignee:
HITACHI LTD (JP)
International Classes:
C12M1/00; C12M1/34; G01N27/00
Domestic Patent References:
| WO2015068673A1 | 2015-05-14 | |||
| WO2012157389A1 | 2012-11-22 | |||
| WO2003048203A1 | 2003-06-12 |
Foreign References:
| JP2016082893A | 2016-05-19 | |||
| JP2016057263A | 2016-04-21 | |||
| JP2004528559A | 2004-09-16 | |||
| US5795782A | 1998-08-18 |
Other References:
JUSUI: "Jusuiso Kokan", SEIKAGAKU JITEN (3RD EDITION), 1998, pages 680 - 681
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
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