Title:
ELECTROSPRAY IONIZATION METHOD AND DEVICE, AND ANALYSIS METHOD AND DEVICE
Document Type and Number:
WIPO Patent Application WO/2011/071182
Kind Code:
A1
Abstract:
Provided is a method that can analyze a tissue or other sample that has not undergone preprocessing. Said sample is inserted into the tip section of a hollow insulating sample holder (11), said tip section having a small hole (11a) opened therein. A thin metal wire (12) is inserted into the sample holder (11) from the back, and while in contact with the sample inside the sample holder (11), the thin metal wire is made to protrude outside the sample holder (11) through the hole (11a). A high voltage is applied to the thin metal wire (12) during at least part of the time when the tip of said thin metal wire (12) is protruding outside from the hole (11a). The sample adhered to the tip of the thin metal wire (12) is ionized via electrospray, introduced into an analysis device, and analyzed.
Inventors:
HIRAOKA KENZO (JP)
Application Number:
PCT/JP2010/072511
Publication Date:
June 16, 2011
Filing Date:
December 08, 2010
Export Citation:
Assignee:
UNIV YAMANASHI (JP)
HIRAOKA KENZO (JP)
HIRAOKA KENZO (JP)
International Classes:
H01J49/10; G01N27/62
Domestic Patent References:
| WO2005104181A1 | 2005-11-03 | |||
| WO2003065405A1 | 2003-08-07 |
Foreign References:
| JPH10112279A | 1998-04-28 | |||
| JPH09510879A | 1997-11-04 | |||
| JP2006134877A | 2006-05-25 | |||
| JPH09304344A | 1997-11-28 |
Other References:
MIZUNO; TSUYAMA; HARADA; MASUJIMA: "Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification", J. MASS SPECTROM., vol. 43, 2008, pages 1692 - 1700, XP055002868, DOI: doi:10.1002/jms.1460
See also references of EP 2511941A4
See also references of EP 2511941A4
Attorney, Agent or Firm:
USHIKU Kenji et al. (JP)
Ushiku Kenji (JP)
Ushiku Kenji (JP)
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