ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE

Title:

ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE

Document Type and Number:

WIPO Patent Application WO/2011/032139

Kind Code:

A3

Abstract:

Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth, ϊn some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid m nerve regeneration and growth along the guide.

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Inventors:

SIMPSON DAVID (US)
BOWLIN GARY (US)
COLELLO RAYMOND (US)
CHOW WOON (US)
JHA BALENDU SHEKHAR (US)

Application Number:

PCT/US2010/048744

Publication Date:

July 07, 2011

Filing Date:

September 14, 2010

Export Citation:

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Assignee:

UNIV VIRGINIA COMMONWEALTH (US)
SIMPSON DAVID (US)
BOWLIN GARY (US)
COLELLO RAYMOND (US)
CHOW WOON (US)
JHA BALENDU SHEKHAR (US)

International Classes:

A61F2/02; A61F2/04; A61L27/14; A61L27/54; B29C33/02

Foreign References:

US20050112349A1	2005-05-26
US20060159718A1	2006-07-20
US20020156150A1	2002-10-24
US20070087025A1	2007-04-19

Attorney, Agent or Firm:

WHITHAM, Michael, E. et al. (Curtis Christofferson & Cook, PC,11491 Sunset Hills Road, Suite 34, Reston VA, US)

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