Title:
β-ELEMENE DERIVATIVE CONTAINING PHOTOAFFINITY GROUP DIAZIRINE, PREPARATION METHOD THEREFOR, AND USE THEREOF AS PHOTOAFFINITY MOLECULAR PROBE
Document Type and Number:
WIPO Patent Application WO/2024/066548
Kind Code:
A1
Abstract:
The present invention provides a β-elemene derivative containing the photoaffinity group diazirine, a preparation method therefor, and use thereof as a photoaffinity molecular probe. The present invention provides a compound of a structure represented by general formula (I), a pharmaceutical composition and a hydrate comprising the compound of general formula (I), and an isotopic derivative, a chiral isomer, a variant, different salts, a prodrug, a formulation, etc. of the compound. Further disclosed herein are a preparation method for the β-elemene derivative containing the photoaffinity group diazirine and use, and the antiproliferative activity of the compound against various tumor cell strains, and the compound is used in β-elemene interaction protein screening. The β-elemene photoaffinity molecular probe in the present invention is expected to become a molecular tool for elemene target screening and studies on the mechanism of action.
Inventors:
XIE TIAN (CN)
YE XIANGYANG (CN)
ZHANG YINGQIAN (CN)
MAO QING (CN)
WU CHENYUAN (CN)
BAI RENREN (CN)
YE XIANGYANG (CN)
ZHANG YINGQIAN (CN)
MAO QING (CN)
WU CHENYUAN (CN)
BAI RENREN (CN)
Application Number:
PCT/CN2023/102980
Publication Date:
April 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
UNIV HANGZHOU NORMAL (CN)
International Classes:
C07D203/04; A61P35/00; C07D487/04; G01N33/68
Foreign References:
| CN115536567A | 2022-12-30 | |||
| CN1850779A | 2006-10-25 | |||
| CN114591201A | 2022-06-07 | |||
| CN106866418A | 2017-06-20 | |||
| CN109593062A | 2019-04-09 | |||
| CN111087344A | 2020-05-01 | |||
| CN114907197A | 2022-08-16 | |||
| US20060014987A1 | 2006-01-19 |
Other References:
DATABASE Registry 4 May 2023 (2023-05-04), ANONYMOUS: "7,10-Dioxa-3,13-diazaoctadec-17-ynamide, N-[2-[2-[2-[5-[2-[(1R,3S,4S)-4-ethenyl-4-methyl-3-(1- methylethenyl)cyclohexyl]-2-propen-1-yl]hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl]ethoxy]ethoxy]ethyl]-2-[2-(3-methyl-3H-diazirin-3-yl)ethyl]-4,14- dioxo-, (2R)- (CA INDEX NAME)", XP093154869, retrieved from STNext Database accession no. 2922710-09-4
JICHAO CHEN: "Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H 2 O 2 -Induced Apoptosis", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 4, 13 April 2017 (2017-04-13), US , pages 443 - 448, XP093154150, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.7b00035
JICHAO CHEN: "Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H 2 O 2 -Induced Apoptosis", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 4, 13 April 2017 (2017-04-13), US , pages 443 - 448, XP093154150, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.7b00035
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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