Title:
β-ELEMENE VINYLATION COUPLED DERIVATIVE, AND PREPARATION THEREOF AND USE THEREOF IN PREPARATION OF ANTITUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2023/160035
Kind Code:
A1
Abstract:
A β-elemene vinylation coupled derivative, and a preparation method therefor and the use thereof in the preparation of an antitumor drug. Provided are a β-elemene vinylation coupled derivative having a structure as represented by formula (I), a pharmaceutical composition and a hydrate containing a compound of formula (I), and an isotopic derivative, a chiral isomer, an allosteric substance, a salt, a prodrug, a preparation, etc., of the compounds. Further provided are a method for preparing the β-elemene vinylation coupled derivative, the use thereof, and the inhibitory activity of the compounds on the proliferation of various tumor cell lines. The β-elemene vinylation coupled derivative is expected to be an antitumor drug candidate for the treatment of colon cancer and lung cancer.
Inventors:
XIE TIAN (CN)
YE YANG (CN)
XU BING (CN)
YE XIANGYANG (CN)
YE YANG (CN)
XU BING (CN)
YE XIANGYANG (CN)
Application Number:
PCT/CN2022/132420
Publication Date:
August 31, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
UNIV HANGZHOU NORMAL (CN)
International Classes:
C07C43/215; A61K31/015; A61K31/03; A61K31/085; A61K31/136; A61K31/166; A61K31/235; A61K31/277; A61K31/36; A61K31/404; A61K31/4196; A61K31/44; A61K31/47; A61K31/495; A61K31/505; A61K31/5375; A61P35/00; C07B37/00; C07C13/28; C07C17/263; C07C22/08; C07C25/24; C07C41/30; C07C67/343; C07C69/76; C07C69/767; C07C209/68; C07C211/45; C07C253/30; C07C255/50; C07C259/10; C07D209/08; C07D213/64; C07D213/73; C07D215/06; C07D239/26; C07D249/08; C07D295/033; C07D295/205; C07D317/50
Foreign References:
| CN114524716A | 2022-05-24 | |||
| EP3034610A1 | 2016-06-22 | |||
| CN110683932A | 2020-01-14 | |||
| CN1850779A | 2006-10-25 | |||
| CN110683932A | 2020-01-14 |
Other References:
YE YANG, QI XIANG, XU BING, LIN YING, XIANG HUAN, ZOU LIANG, YE XIANG-YANG, XIE TIAN: "Nickel-catalyzed cross-electrophile allylation of vinyl bromides and the modification of anti-tumour natural medicine β-elemene", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 13, no. 23, 15 June 2022 (2022-06-15), United Kingdom , pages 6959 - 6966, XP093088893, ISSN: 2041-6520, DOI: 10.1039/D2SC02054H
BAI, RENREN ET AL.: "Rational Design, Synthesis and Biological Evaluation of Novel Derivatives Based on In Vivo Metabolism of Natural Product β-elemene", LETTERS IN DRUG DESIGN & DISCOVERY, vol. 15, no. 8, 31 August 2018 (2018-08-31), pages 905 - 912, XP009548589, ISSN: 1875-628X
BAI, RENREN ET AL.: "Rational Design, Synthesis and Biological Evaluation of Novel Derivatives Based on In Vivo Metabolism of Natural Product β-elemene", LETTERS IN DRUG DESIGN & DISCOVERY, vol. 15, no. 8, 31 August 2018 (2018-08-31), pages 905 - 912, XP009548589, ISSN: 1875-628X
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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