| WO1989009604A1 | 1989-10-19 |
| US6531506B1 | 2003-03-11 | |||
| US6203820B1 | 2001-03-20 |
| Claims 1-I claim the patent as this is an invention and industrially applicable, involving new application of known industrial processing. (Part 1- Article 1). |
| 2-I claim the right that the patent shall belong to the inventor or his successor in title. |
| 3-I claim the protection period of 20 years. (Part 1-Article 9). |
| 4-I claim the right to end product protection. |
| 5-1 claim the right to prevent a third party from exploiting the invention by any means: importing, using, selling, advertising or distributing the product (Part 1-Aricle 10). |
| 6-I claim the right for manufacturing, processing sulfur in its elemental form or in acid salts, combined and/or formulated with R as a medical product in all forms as medicine, medical foods, artificial milks and all medicaments. |
| R degree is, independently, any member selected from the group of any acids and any acid salts derivatives. |
| R is----O, where the sulfate formed can be combined with any acids and any acid salt derivatives. |
| R is all compounds able to form final formulation releasing elemental sulfur (subject invention). |
| AMENDED CLAIMS received by the International Bureau on 20 October 2004 (20.10. 04): claims 1 to 6 have been replaced by claims 1 to 1 1. t Amended Claims: I claim the use of the following medically as medicines and medical interventional material: 1. Inorganic native sulfur in any of its forms as open or cyclic S,, species, liquid, catenasulf ur. |
| Where,, =6, 7, 9-15, 18, and 20, and any other form of elemental inorganic sulfur. |
| 2. A structure having the formula ofR-sulfide (R-S). |
| 3. A structure having the formula of R-hydrogen suliide (R-SH) in inorganic compounds. |
| 4. A structure having the formula of R-thiol (R-SH) in organic compounds, 5. A structure having the formula of Sulfur-R (S-R) 6. A structure having the formula of sulfur nitrogen cations and anions. (R-SN) 7. A structure having the formula of disulfide (RSSR). |
| 8. A structure having the formula of R-dithiocarbamate, R-ditlliocaboxylatc R- dithiophosphinate, R-thioxanthate, R-trithiocarbonate. |
| 9. A structure having the formula of R-tetrathiometallate. |
| 10. A structure having the formula ofR-dithiolenes. |
| Where R is independently selected from: all acid addition sulfides, acid addition hydrogen sulfides, base addition sulfides and hydrogen sulfides). a. All elements of The Periodic Table of the elements including : Metals. actinide, lanthanides, first, second, and third transition elements series and the halogens (example : all phosphorus sulphides, all potassium sulfides, sulfuu chlorides, sulfur amide (S4N') tetrasulfur tetranitride, S. N,. compounds etc.,). b. Amino acids (any essential or non-essential, primary amines, secondary amines, tertiary amines, arylamines, heterocyclic amines, aromatic amines. c. Lipoproteins, apolipoproteins, lethicines, eicosanoids. d. Fatty acids, alkanes, alkenes, alkynes, aromatics, alkyl halides, haloalkenes, alcohols, ethers, amines, aldehydes, ketones, carboxylic acids, esters, amides, nitriles. e. Isoprenoids, steroids, cholesterol and its biosynthesis steps products. f. Water soluble vitamins and fat soluble vitamins (example : pyridoxin sulfide-thiol, pantothenate sulfide-thiol etc). g. Casein, olivovitelline. h. Ketones, polyhydroxy aldehydes. i. D and L Glyceraldhydes, lactic acid, tartaric acid, arabinose j. Carbohydrates; as Monosaccharides, (including aldehydes, ketones) as trioses, tetroses, pentoses, hexoses, Disaccharides, uronic acids, aric acids, anhydrides, dianhydrides, glycosides, cyclic acetals, aldoses, uloses, aldonic acids, k. Invert sugars (example ; dextrose, levulose, etc) 1. Glucosamine and glucouronic acid m. Phosphatidic acids, phosphatidylcholines, phosphatidylethanolamines, n. Phosphatydylserines, phosphatidylinositols. o. Hormones and biologic mediators (example: neurotransmitters, adrenalin, amphetamines, dopamine, serotonin, thyroxin). p. Oligomeric proteins (including angiotensin II, vasopressin, oxytocin, bradykinin, gastrin, substance P, and endothelin, etc) q. Bulking agents and sclerosing agents r. Bile acids (example : cholic acid, dexoxy cholic acid, taurocholic acid, glycocholic acid, lithocholic acid, chenodeoxy cholic acid etc). |
| 11. Plastic of sulfur and all acid addition sulfides, acid addition hydrogen sulfides, base addition sulfides and hydrogen sulfides for the making of all medical interventional material. |
| Where Medical interventional material includes (vascular, cardiologic, endovascular, urologic, hepatic, neurologic, gastrointestinal, cardiothoracic, orthopedic) Stents, (including endovascular, dilating, urethra, ureteric) catheters,---ostomy tubes, Chest tube . Bulking agents for incontinence, reflux, Drains, shunts, nerve sheathing material, Tubes (including tracheostomy, grommet) Surgical suture material. |
| Sieves for venous and arterial thrombosis. |
| Plastic bags for blood, urine, and any biologic material. |
| * Canulas, central venous pressure devices, Grafts, (including grafts replacing bone defects and other soft tissue defects post-debulking, or post traumatic or congenital etc.) Prosthesis devices (including penile, breast implants, heart valves, etc.). |
| Casts, soft and hard, * Implants (including absorbable implants) Plates and screws, nails, Spacers, Bone cement. |
| Bands for band ligations, and ligations for all medical purposes as fallopian tube ligation, cervical, oeophageal varices etc. |
| Sheaths of endoscopy, bed sheets, thermometers, etc |
Elemental sulfur as an oral or parentral medical product The prior art: Environmental pollutants as Epoxides, arene oxide, nitro groups, hydroxylamines and aflatoxins need Glutathione conjugation where the endogenous reactant is Glutathione in the presence of Glutathione S Transferase (cytosol microsomes). Since Glutathione is the major intracellular soluble sulfahydryl-containing compound, factors that regulate the biosynthesis and the composition have important consequences. The Glutathione conjugation is a common pathway for detoxification of primary metabolites to reduced Glutathione. These water soluble secondary metabolites are readily excreted in the bile and urine. Glutathione conjugation defects leads to accumulation of environmental pollutants. Treatment of the resultant diseases and syndromes were targeted at supplying sulfur as sulphates of different organic and inorganic substances with side effects related to these substances.
The problem: All the earlier e xperiences a ddressed t he s ymptomatology o f t he disease and none addressed the aetiology which was obscure. None provided the sulfur to bypass the deficiency of the glutathione S transferase to detoxify all the ingested or inhaled toxins.
The new in the invention: Elemental Sulfur and its acid addition salts and derivatives for Glutathione S Transferase heterozygous and homozygous disorders and Epoxide Hydrolase heterozygous and homozygous disorders.
Title element and its acid addition salts and derivatives are physiologically acceptable, essential and are readily converted to acceptable counter parts by established procedures, they are pharmacologically active on the liver, lungs, hematopoetic system and all body systems and all malignancies and the autoimmune and immune mediate disorders and are thus useful when administered to warm blooded animals to induce detoxification of many endogenous and
exogenous metabolites. They are useful in terminating diseases associated with Glutathione S Transferase and Epoxide Hydrolase disorders.
The elemental sulfur provides the body and liver cells by the essential sulfur to bind to toxic material and thus is eliminated in bile.
Sulfur is absorbed from the small intestines as sulfates with essential amino-acids or as a salt to other acids.
These compounds are prepared as elemental or as salts or as acid addition salts and derivatives compounds. They are simply elemental or compounded into different dosage-multi form medicament compositions.
The detailed Description: Pure sulfur element and/or its acid addition salts and derivatives are prepared by all industrial techniques and processes, and bound by any binder.
Industrial applicability: Inclusion of Elemental Sulfur and/or its acid addition salts and derivatives in management protocols of Glutathione S Transferase heterozygous and homozygous disorders and Epoxide Hydrolase heterozygous and homozygous disorders, and glutathione depletion associated syndromes.