Title:
ELONGASE GENES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2000012720
Kind Code:
A3
Abstract:
The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogama linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, omega 6-docosapentaenoic acid or omega 3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
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Inventors:
MUKERJI PRADIP
LEONARD AMANDA EUN-YEONG
HUANG YUNG-SHENG
THURMOND JENNIFER
KIRCHNER STEPHEN J
PARKER-BARNES JENNIFER M
DAS TAPAS
LEONARD AMANDA EUN-YEONG
HUANG YUNG-SHENG
THURMOND JENNIFER
KIRCHNER STEPHEN J
PARKER-BARNES JENNIFER M
DAS TAPAS
Application Number:
PCT/US1999/019715
Publication Date:
September 08, 2000
Filing Date:
August 30, 1999
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
A01H5/00; A01K67/027; A23C11/02; A23D9/00; A23K1/16; A23L1/30; A23L33/00; A61K8/30; A61K8/36; A61K8/60; A61K8/64; A61K31/202; A61P1/04; A61P3/06; A61P3/10; A61P3/14; A61P7/02; A61P9/00; A61P9/08; A61P11/06; A61P13/12; A61P15/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P19/10; A61P21/00; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61Q19/00; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N9/10; C12N15/09; C12N15/54; C12N15/82; C12P7/64; A61K38/00; C12R1/645; C12R1/865; (IPC1-7): C12N15/54; C12N9/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; A01K67/027; A23D9/00; A23L1/29; A61K31/20; A61K7/00
Domestic Patent References:
| WO1988007577A1 | 1988-10-06 |
Foreign References:
| EP0296751A1 | 1988-12-28 | |||
| FR2648347A1 | 1990-12-21 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 08 30 June 1998 (1998-06-30)
DATABASE EMBL 30 May 1995 (1995-05-30), HILLIER L, ET AL.: "Homo sapiens clone 138518 (EST)", XP002131823
SALEM N, ET AL.: "Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 93, January 1996 (1996-01-01), pages 49 - 54, XP002131822
DATABASE EMBL 30 May 1995 (1995-05-30), HILLIER L, ET AL.: "Homo sapiens clone 138518 (EST)", XP002131823
SALEM N, ET AL.: "Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 93, January 1996 (1996-01-01), pages 49 - 54, XP002131822
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