Title:
EMBRYONIC MACROPHAGES AND CELL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2023/153479
Kind Code:
A1
Abstract:
A cell population which contains 75% or more of CD11b positive, F4/80 positive, CD180 positive and CD9 positive macrophages derived from a tissue selected from the group consisting of placenta, umbilical cord and amnion, and which contains 80% or more of viable cells.
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Inventors:
SAKAI SHIGEKI (JP)
KISHI KAZUO (JP)
KISHI KAZUO (JP)
Application Number:
PCT/JP2023/004391
Publication Date:
August 17, 2023
Filing Date:
February 09, 2023
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
C12N5/0786; A61K8/98; A61K9/08; A61K35/50; A61K35/51; A61P1/04; A61P1/16; A61P11/00; A61P17/00; A61P17/02; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; A61Q19/00; A61Q19/08
Other References:
NA QUAN; CHUDNOVETS ANNA; LIU JIN; LEE JI YEON; DONG JIE; SHIN NA; ELSAYED NADA; LEI JUN; BURD IRINA: "Placental Macrophages Demonstrate Sex-Specific Response to Intrauterine Inflammation and May Serve as a Marker of Perinatal Neuroinflammation", JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ELSEVIER SCIENCE IRELAND LTD., IE, vol. 147, 29 July 2021 (2021-07-29), IE , XP086783573, ISSN: 0165-0378, DOI: 10.1016/j.jri.2021.103360
EDLOW ANDREA G.; GLASS RUTHY M; SMITH CAROLINE J; TRAN PHUONG KIM; JAMES KAITLYN; BILBO STACI: "Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity", INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE., PERGAMON, OXFORD., GB, vol. 77, 20 November 2018 (2018-11-20), GB , pages 60 - 68, XP085801598, ISSN: 0736-5748, DOI: 10.1016/j.ijdevneu.2018.11.004
NAKAMURA YUKIE: "Skin regeneration mechanism, analysis of embryonic skin macrophages", KAKENHI-PROJECT-18K16999, 1 January 2019 (2019-01-01), XP093084588, Retrieved from the Internet [retrieved on 20230922]
Ó MAOLDOMHNAIGH CILIAN, COX DONAL J., PHELAN JAMES J., MALONE FERGAL D., KEANE JOSEPH, BASDEO SHAREE A.: "The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages", FRONTIERS IN IMMUNOLOGY, vol. 12, 13 April 2021 (2021-04-13), pages 657261, XP093084589, DOI: 10.3389/fimmu.2021.657261
BULMER J. N, JOHNSON P. M: "Macrophage populations in the human placenta and amniochorion", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 57, no. 2, 1 August 1984 (1984-08-01), GB , pages 393 - 403, XP093084590, ISSN: 0009-9104
EDLOW ANDREA G.; GLASS RUTHY M; SMITH CAROLINE J; TRAN PHUONG KIM; JAMES KAITLYN; BILBO STACI: "Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity", INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE., PERGAMON, OXFORD., GB, vol. 77, 20 November 2018 (2018-11-20), GB , pages 60 - 68, XP085801598, ISSN: 0736-5748, DOI: 10.1016/j.ijdevneu.2018.11.004
NAKAMURA YUKIE: "Skin regeneration mechanism, analysis of embryonic skin macrophages", KAKENHI-PROJECT-18K16999, 1 January 2019 (2019-01-01), XP093084588, Retrieved from the Internet
Ó MAOLDOMHNAIGH CILIAN, COX DONAL J., PHELAN JAMES J., MALONE FERGAL D., KEANE JOSEPH, BASDEO SHAREE A.: "The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages", FRONTIERS IN IMMUNOLOGY, vol. 12, 13 April 2021 (2021-04-13), pages 657261, XP093084589, DOI: 10.3389/fimmu.2021.657261
BULMER J. N, JOHNSON P. M: "Macrophage populations in the human placenta and amniochorion", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 57, no. 2, 1 August 1984 (1984-08-01), GB , pages 393 - 403, XP093084590, ISSN: 0009-9104
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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