Title:
EMODIN SUCCINYL ESTER COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/109873
Kind Code:
A1
Abstract:
Disclosed in the present invention are an emodin succinyl ester compound, a preparation method therefor and a use thereof, the emodin succinyl ester compound having the structure as represented by formula I (R being a C1-5 alkyl group). The method provided in the present invention has a simple method course, and may effectively save time in synthesis and reduce costs, being simple to operate, being easy to implement, and being suitable for industrial production. Experiments show that the emodin succinyl ester compound of the present invention may better promote the healing of diabetic wounds than emodin, and may be used for preparing a drug for promoting the healing of diabetic wounds. Moreover, it has been confirmed by means of performing pharmacological experiments on rats suffering from experimentally mixed hyperlipidemia that the emodin succinyl ester compound of the present invention is superior to emodin, and has the advantages of having a remarkable blood fat lowering effect, being safe, being simple and convenient to administer, the raw materials being low cost and readily available, and being easy to transport and store.
Inventors:
YANG BAOFENG (CN)
XIAO WEI (CN)
ZHANG YONG (CN)
DU ZHIMIN (CN)
WANG JINHUI (CN)
WANG ZHENZHONG (CN)
BAI YUNLONG (CN)
LV YANJIE (CN)
HUANG XUESHI (CN)
XU CHAOQIAN (CN)
LI XIN (CN)
XIAO WEI (CN)
ZHANG YONG (CN)
DU ZHIMIN (CN)
WANG JINHUI (CN)
WANG ZHENZHONG (CN)
BAI YUNLONG (CN)
LV YANJIE (CN)
HUANG XUESHI (CN)
XU CHAOQIAN (CN)
LI XIN (CN)
Application Number:
PCT/CN2018/118698
Publication Date:
June 13, 2019
Filing Date:
November 30, 2018
Export Citation:
Assignee:
JIANGSU KANION PARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/00; C07C69/40; A61K31/225; A61P3/06; A61P3/10; A61P17/02; C07C67/08; C07C67/14; C07C67/30; C07C67/56; C07C69/67; C07C69/675
Foreign References:
| CN105663099A | 2016-06-15 | |||
| CN108186623A | 2018-06-22 | |||
| CN108047046A | 2018-05-18 |
Other References:
See also references of EP 3725761A4
Attorney, Agent or Firm:
BEIJING LAWSING IP FIRM (CN)
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