Title:
EMULSION AND MICELLAR FORMULATIONS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES TO CELLS
Document Type and Number:
WIPO Patent Application WO1997011682
Kind Code:
A3
Abstract:
New emulsion and micelle formulations are described as are complexes of these formulations with biologically active substances. The novel formulations are different from cationic lipid vectors such as cationic liposomes in that the complexes formed between biologically active substances and the emulsion and micellar formulations of this invention are physically stable and their transfection activity is resistant to the presence of serum. These novel formulations are disclosed to be useful in areas such as gene therapy or vaccine delivery.
Inventors:
LIU DEXI
LIU FENG
YANG JING-PING
HUANG LEAF
LIU FENG
YANG JING-PING
HUANG LEAF
Application Number:
PCT/US1996/015388
Publication Date:
July 10, 1997
Filing Date:
September 26, 1996
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
International Classes:
A61K9/107; A61K31/70; A61K31/7088; A61K38/00; A61K39/00; A61K47/18; A61K47/24; A61K48/00; (IPC1-7): A61K9/107
Domestic Patent References:
| WO1995012384A1 | 1995-05-11 | |||
| WO1993018852A1 | 1993-09-30 | |||
| WO1993005162A1 | 1993-03-18 |
Foreign References:
| EP0387647A2 | 1990-09-19 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 18, no. 337 (C - 1217) 27 June 1994 (1994-06-27)
TREINER C. ET AL: "Micellar solubilization in aqueous binary surfactant systems : barbituric acids in mixed anionic + nonionic or cationic + nonionic mixtures", J. COLLOID INTERFACE SCI., vol. 125, no. 1, 1988, pages 261 - 270, XP000645802
FARHOOD H. ET AL: "Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity", BIOCHIM. BIOPHYS. ACTA, vol. 1111, no. 2, 1992, pages 239 - 246, XP000607577
BOTTEGA R. ET AL: "Inhibition of protein kinase C by cationic amphiphiles", BIOCHEMISTRY, vol. 31, 1992, pages 9025 - 9030, XP000645334
TREINER C. ET AL: "Micellar solubilization in aqueous binary surfactant systems : barbituric acids in mixed anionic + nonionic or cationic + nonionic mixtures", J. COLLOID INTERFACE SCI., vol. 125, no. 1, 1988, pages 261 - 270, XP000645802
FARHOOD H. ET AL: "Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity", BIOCHIM. BIOPHYS. ACTA, vol. 1111, no. 2, 1992, pages 239 - 246, XP000607577
BOTTEGA R. ET AL: "Inhibition of protein kinase C by cationic amphiphiles", BIOCHEMISTRY, vol. 31, 1992, pages 9025 - 9030, XP000645334
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