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Title:
EMULSION OF PERFLUORORGANIC COMPOUNDS EXHIBITING GAS-TRANSPORT PROPERTIES, A SURFACE-ACTIVE AGENT FOR SAID EMULSION AND METHOD FOR THE PRODUCTION THEREOF.
Document Type and Number:
WIPO Patent Application WO/2004/047804
Kind Code:
A1
Abstract:
The group of inventions relates to medicine and colloid chemistry and can be used for producing gas-transport function blood substitutes, medicinal and cosmetic preparations and food additives. Said group of inventions makes it possible to obtain a high emulsion stability for long-term storage, in particular the storage at an above-zero temperature during an year, the emulsion stability to sterilisation (autoclaving), produce an emulsion with particle sizes less than 250 nm at an narrow dispersiveness thereof, increase the oxygen capacity and eliminate the toxicity of intravenously injected doses of 15-20 ml/kg. Said inventions are characterised in that tocopherol polyethylenglycol ester is used in the form of a surface-active substance for producing emulsion of perfluororganic compounds exhibiting gas-transport properties. The inventive emulsion contains a mixture of perfluororganic compounds and a surface-active substance which is embodied at least in the form of tocopherol polyethylenglycol ester or the mixture thereof with other nonionogenic surface-active substances. The inventive method for producing said emulsion consists in stabilising a mixture of perfluordecalin and perfluoro-n-methylcyclohexylpiperidine by an surface-active substance in the form of tocopherol polyethylenglycol ester or the mixture thereof with other nonionogenic surface-active substances.

Inventors:
Kalinichenko, Alla Nikolaevna (Likhachevskoe shosse, 20-3-45 Dolgoprudny, Moskovskaya obl. 0, 14170, RU)
Kaptsov, Vladimir Vasilievich (mkr. AB, 9-74 Puschin, Moskovskaya obl. 0, 14229, RU)
Lazarev, Mikhail Ivanovich (mkr. AB, 34-2 Puschin, Moskovskaya obl. 0, 14229, RU)
Application Number:
PCT/RU2002/000431
Publication Date:
June 10, 2004
Filing Date:
September 25, 2002
Export Citation:
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Assignee:
Obshestvo, Ogranichennoi Otvetstvennostiu Accent C. (ul. Bolshaya Gruzinskaya, 60-1 Moscow, 6, 12305, RU)
Kalinichenko, Alla Nikolaevna (Likhachevskoe shosse, 20-3-45 Dolgoprudny, Moskovskaya obl. 0, 14170, RU)
Kaptsov, Vladimir Vasilievich (mkr. AB, 9-74 Puschin, Moskovskaya obl. 0, 14229, RU)
Lazarev, Mikhail Ivanovich (mkr. AB, 34-2 Puschin, Moskovskaya obl. 0, 14229, RU)
International Classes:
A61K9/00; A61K31/025; A61K31/435; A61K47/14; A61K47/24; (IPC1-7): A61K9/107; A61K31/025; A61K31/435; A61K47/22; B01J17/42
Foreign References:
EP0399842A2
RU2000123238A
RU96105703A1998-06-10
US5393513A
RU2181998C2
Other References:
KUZNETSOV I. N.: 'Emulsia perftoruglerodov i ikh effektivnost' KHIM, PHARM. JURNAL vol. 26, no. 11-12, pages 28 - 31, XP008102446
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