ENA ANTISENSE OLIGONUCLEOTIDE HAVING SEQUENCE-SPECIFIC ACTION

Title:

ENA ANTISENSE OLIGONUCLEOTIDE HAVING SEQUENCE-SPECIFIC ACTION

Document Type and Number:

WIPO Patent Application WO/2008/029619

Kind Code:

A1

Abstract:

It is intended to provide an antisense oligonucleotide that can specifically cleave a target sequence. The antisense oligonucleotide represented by the following sequence (I) or a pharmacologically acceptable salt thereof. Wing1-R11-Window-R12-Wing2 (I) (In the sequence (I), Window represents a deoxyribonucleotide sequence having 5 or 6 nucleotides, R11 and R12 each independently represent a ribonucleotide, Wing1 and Wing2 each independently represent a ribonucleotide, a ribonucleotide sequence, a deoxyribonucleotide, a deoxyribonucleotide sequence or a mixed sequence of a ribonucleotide and a deoxyribonucleotide. In the case where Wing1 is a deoxyribonucleotide sequence or a mixed sequence of a ribonucleotide and a deoxyribonucleotide, 4 or more deoxyribonucleotides are not consecutively linked in the sequence, and in the case where Wing2 is a deoxyribonucleotide sequence or a mixed sequence of a ribonucleotide and a deoxyribonucleotide, 4 or more deoxyribonucleotides are not consecutively linked in the sequence. In at least one ribonucleotide constituting the sequence of Wing1-R11 or R12-Wing2, 2'-O and 4'-C in the sugar moiety are crosslinked via a C1-4 alkylene chain.)

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Inventors:

KOIZUMI, Makoto (LIMITED 1-2-58, Hiromachi, Shinagawa-k, Tokyo 10, 1408710, JP)
小泉誠 (〒10 東京都品川区広町一丁目２番５８号第一三共株式会社内 Tokyo, 1408710, JP)

Application Number:

JP2007/066244

Publication Date:

March 13, 2008

Filing Date:

August 22, 2007

Export Citation:

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Assignee:

DAIICHI SANKYO COMPANY, LIMITED (3-5-1, Nihonbashi Honcho Chuo-k, Tokyo 23, 1030023, JP)
第一三共株式会社 (〒23 東京都中央区日本橋本町三丁目５番１号 Tokyo, 1030023, JP)
KOIZUMI, Makoto (LIMITED 1-2-58, Hiromachi, Shinagawa-k, Tokyo 10, 1408710, JP)

International Classes:

C12N15/09; A61K31/712; A61K48/00; A61P1/04; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/06; A61P13/08; A61P13/10; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/12; A61P31/16; A61P31/22; A61P35/00; A61P35/02; A61P37/08; C07H21/04; C12N15/09; A61K31/712; A61K48/00; A61P1/00; A61P3/00; A61P7/00; A61P9/00; A61P11/00; A61P13/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/00; C07H21/00

Attorney, Agent or Firm:

MAYAMA, Setsuko et al. (Nohki-kaikan Fourth Floor, 30-1 Tsuruyacho 3-chome, Kanagawa-ku, Yokohama-sh, Kanagawa 35, 2210835, JP)

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