ENDOCRINE PANCREAS DIFFERENTIATION OF ADIPOSE TISSUE-DERIVED STROMAL CELLS AND USES THEREOF

WIPO Patent Application WO2003039489

A3

The invention provides cells, compositions and methods based on the differentiation of adipose tissue-derived stromal cells into a cell expressing at least one genotypic or phenotypic characteristic of a pancreas cell. The cells produced in the method are useful in providing a source of differentiated and functional cells for research, implantation, transplantation and development of tissue engineered products for the treatment of diseases of the pancreas and pancreatic tissue repair.

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CHEATHAM BENTLEY (US)
HALVORSEN YUAN-DI C (US)
GIMBLE JEFFREY M (US)

PCT/US2002/036373

January 29, 2004

November 12, 2002

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ARTECEL SCIENCES INC (US)
CHEATHAM BENTLEY (US)
HALVORSEN YUAN-DI C (US)
GIMBLE JEFFREY M (US)

A61K48/00; C12P21/02; A61L27/00; A61P3/06; A61P3/10; A61P5/48; C12N5/00; C12N5/071; C12N5/10; A61K35/12; (IPC1-7): C12N5/05; C12N5/08

WO2001062901A2	2001-08-30
WO2000053795A1	2000-09-14

LUMELSKY ET AL.: "Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets", SCIENCE, vol. 292, 18 May 2001 (2001-05-18), pages 1389 - 1394, XP002183377

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