Title:
ENDOMETRIOSIS LESION-TARGETED NANO-DELIVERY SYSTEM, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/016752
Kind Code:
A1
Abstract:
An endometriosis lesion-targeted nano-delivery system, and a preparation method therefor and the use thereof. The delivery system comprises a hydrophobic inner core, which is located at the center, a lipid monomolecular layer around the hydrophobic inner core, and a hydrophilic targeting polypeptide layer. The polypeptide comprises a polypeptide formed by combining one or more of the following sequences or a derivative of the polypeptide formed by combining one or more of the following sequences: SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6. By means of using a nanoparticle encapsulating technique in combination with the surface modification of the polypeptide having a targeting capability, an endometriosis lesion can be specifically recognized, thereby providing an efficient drug delivery system for diagnosis and treatment of such patients. Since the nanoparticle encapsulating technique can be used to deliver a suitable diagnostic reagent or therapeutic drug to a lesion site, the use thereof as a diagnostic and therapeutic tool can be achieved.
Inventors:
ZHAO HUASHAN (CN)
ZHANG JIAN (CN)
ZHANG PENGFEI (CN)
ZHANG JIAN (CN)
ZHANG PENGFEI (CN)
Application Number:
PCT/CN2020/129878
Publication Date:
January 27, 2022
Filing Date:
November 18, 2020
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K47/42; A61P15/00
Domestic Patent References:
| WO2019061648A1 | 2019-04-04 |
Foreign References:
| CN109568577A | 2019-04-05 | |||
| CN109387627A | 2019-02-26 | |||
| CN104136041A | 2014-11-05 | |||
| CN106512029A | 2017-03-22 | |||
| CN108567973A | 2018-09-25 |
Other References:
LI MENG, YIN JIGANG; CHEN QIJUN: "Pregnancy-associated malaria and its research progress ", JOURNAL OF TROPICAL MEDICINE, vol. 8, no. 12, 1 December 2008 (2008-12-01), pages 1287 - 1293, XP055889072, ISSN: 1672-3619
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ZHANG BAOZHEN, ZHENG MINGBIN, CAI LINTAO, FAN XIUJUN: "Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles", JOURNAL OF VISUALIZED EXPERIMENTS, JOVE, US, vol. 379158209, no. 139, 1 January 2018 (2018-01-01), US , pages 58209, XP055889083, ISSN: 1940-087X, DOI: 10.3791/58209
NASCIUTTI, L.E. ; FERRARI, R. ; BERARDO, P.T. ; S. SOUZA, M.L. ; TAKIYA, C.M. ; BOROJEVIC, R. ; ABRAO, M.S. ; SILVA, L.C.F.: "Distribution of chondroitin sulfate in human endometrium", MICRON, PERGAMON, OXFORD,, GB, vol. 37, no. 6, 1 August 2006 (2006-08-01), GB , pages 544 - 550, XP027993165, ISSN: 0968-4328
TAO LI, XIA HUI: "Research progress on placental malaria during pregnancy ", JOURNAL OF TROPICAL DISEASES AND PARASITOLOGY, vol. 13, no. 2, 1 January 2015 (2015-01-01), pages 116 - 119, XP055889079, ISSN: 1672-2302, DOI: 10.3969/j.issn.1672-2302.2015.02.021
ZHANG BAOZHEN, ZHENG MINGBIN, CAI LINTAO, FAN XIUJUN: "Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles", JOURNAL OF VISUALIZED EXPERIMENTS, JOVE, US, vol. 379158209, no. 139, 1 January 2018 (2018-01-01), US , pages 58209, XP055889083, ISSN: 1940-087X, DOI: 10.3791/58209
NASCIUTTI, L.E. ; FERRARI, R. ; BERARDO, P.T. ; S. SOUZA, M.L. ; TAKIYA, C.M. ; BOROJEVIC, R. ; ABRAO, M.S. ; SILVA, L.C.F.: "Distribution of chondroitin sulfate in human endometrium", MICRON, PERGAMON, OXFORD,, GB, vol. 37, no. 6, 1 August 2006 (2006-08-01), GB , pages 544 - 550, XP027993165, ISSN: 0968-4328
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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