Title:
ENDOPHYTIC STREPTOMYCETES FROM HIGHER PLANTS WITH BIOLOGICAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO2003085122
Kind Code:
A3
Abstract:
The present invention relates to isolated strains of a Streptomyces spp., which are endophytes of dicotyledonous plants and to methods for selecting such strains. The present invention also relates to compounds having biological activity selected from the group consisting of munumbicin A, munumbicin B, munumbicin C and munumbicin D, kakadumycin A, kakadumycin B, and kakadumycin C. The present invention further relates to compositions of such compounds and to methods of protecting plants against attack by a plant pathogen and methods of inhibiting bacterial growth, fungal growth, viral infection, growth of parasitic organisms, and cancer cell growth with such compositions.
Inventors:
STROBEL GARY A (US)
CASTILLO UVIDELIO F (US)
HARPER JAMES K (US)
YAVER DEBBIE S (US)
CASTILLO UVIDELIO F (US)
HARPER JAMES K (US)
YAVER DEBBIE S (US)
Application Number:
PCT/US2003/010181
Publication Date:
December 01, 2005
Filing Date:
April 03, 2003
Export Citation:
Assignee:
UNIV MONTANA STATE (US)
STROBEL GARY A (US)
CASTILLO UVIDELIO F (US)
HARPER JAMES K (US)
YAVER DEBBIE S (US)
STROBEL GARY A (US)
CASTILLO UVIDELIO F (US)
HARPER JAMES K (US)
YAVER DEBBIE S (US)
International Classes:
A01H17/00; A01N63/28; C07K4/04; C12R1/465; (IPC1-7): C12N1/20
Other References:
BIEBER B. ET AL: "Alnumycin a New Naphthoquinone Antibiotic Produced by an Endophytic Streptomycessp.", JOURNAL OF ANTIBIOTICS., vol. 51, no. 3, March 1998 (1998-03-01), pages 381 - 382, XP008055165
SARDI P. ET AL: "Isolation of endophytic Streptomyces strains from surface sterilized roots.", APPL ENVIRONM MICROBIOL., vol. 58, no. 8, August 1992 (1992-08-01), pages 2691 - 2693, XP002992267
SHIMIZU M. ET AL: "Studies on endophytic Actiomycetes (I) Streptomyces sp. isolated from Rhododendron and its antifungal activity.", GNERAL PLANT PATHOLOGY., vol. 66, no. 4, November 2000 (2000-11-01), pages 360 - 366, XP002992268
SESSITSCH A. ET AL: "Cultivation-independent population analysis of bacterial andophytes in three potato varieties based on eubacterial and Actinomycetes-specific PCR of 16S rRNA genes.", FEMS MICROBIOLOGY ECOLOGY., vol. 39, no. 1, January 2002 (2002-01-01), pages 23 - 32, XP002992269
SARDI P. ET AL: "Isolation of endophytic Streptomyces strains from surface sterilized roots.", APPL ENVIRONM MICROBIOL., vol. 58, no. 8, August 1992 (1992-08-01), pages 2691 - 2693, XP002992267
SHIMIZU M. ET AL: "Studies on endophytic Actiomycetes (I) Streptomyces sp. isolated from Rhododendron and its antifungal activity.", GNERAL PLANT PATHOLOGY., vol. 66, no. 4, November 2000 (2000-11-01), pages 360 - 366, XP002992268
SESSITSCH A. ET AL: "Cultivation-independent population analysis of bacterial andophytes in three potato varieties based on eubacterial and Actinomycetes-specific PCR of 16S rRNA genes.", FEMS MICROBIOLOGY ECOLOGY., vol. 39, no. 1, January 2002 (2002-01-01), pages 23 - 32, XP002992269
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