Title:
ENDOSERINE CONVERTING ENZYME INHIBITOR OR VASCULAR TWITCH REMEDY
Document Type and Number:
WIPO Patent Application WO/1992/001468
Kind Code:
A1
Abstract:
An endoserine converting enzyme inhibitor, a vascular twitching agent or a vascular twitch remedy containing a compound represented by general formula (I) or its salt as the active ingredient, wherein A¿1? and A¿2? represent each amino acid residue, X represents hydroxy or monosaccharide residue, and R¿1? represents hydroxy, alkyl, alkoxy, allyl or -NR¿2?R¿3? wherein R¿2? and R¿3? represent each hydrogen or alkyl. A pharmaceutical preparation containing the compound (I) or its salt as the active ingredient has an activity of inhibiting an endoserine converting enzyme or controlling vascular twitch. Therefore, it is effective in preventing or treating hypertension, bronchial asthma, peripheral circulatory disturbance, cerebrovascular spasm (occurring after cerebral hemorrhage, subarachnoid hemorrhage, etc.), coronary twitch (including attack caused by twitch occurring when a constricted site is reopened by, for example, laser cautery, especially one which is difficultly curable and for which even nitroglycerol is inefficacious, that is, attack caused by postoperational coronary twitch and angina pectoris induced by coronary twitch) and other vascular twitches of mammals including man, pig, cattle, horse, dog, rat and mouse.
Inventors:
MORIMOTO SHIRO (JP)
MATSUMURA YASUO (JP)
UCHIDA TAKESHI (JP)
KIDO HIDEAKI (JP)
SHINYAMA HIROSHI (JP)
MATSUMURA YASUO (JP)
UCHIDA TAKESHI (JP)
KIDO HIDEAKI (JP)
SHINYAMA HIROSHI (JP)
Application Number:
PCT/JP1991/000808
Publication Date:
February 06, 1992
Filing Date:
June 15, 1991
Export Citation:
Assignee:
GREEN CROSS CORP (JP)
International Classes:
A61K38/55; C07K5/06; C07K9/00; A61K38/00; (IPC1-7): A61K37/64
Foreign References:
| GB2207351A | 1989-02-01 | |||
| EP0331105A2 | 1989-09-06 |
Attorney, Agent or Firm:
Takashima, Hajime (3-9 Hiranomachi 3-chome, Chuo-k, Osaka-shi Osaka 541, JP)
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