Title:
ENDOTRACHEAL TUBE LOADED WITH ANTIMICROBIAL PEPTIDE MDC COATING AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/140796
Kind Code:
A1
Abstract:
An endotracheal tube loaded with antimicrobial peptide MDC coating and a preparation method therefor and an application thereof. The endotracheal tube uses antimicrobial peptide MDC as the antibacterial agent and uses chitosan gel as the fixing and slow-release substrate to perform surface coating on the endotracheal tube to make an endotracheal tube loaded with antimicrobial peptide MDC coating. The antimicrobial peptide MDC sequence is shown as SEQ ID NO:1. The endotracheal tube loaded with antimicrobial peptide MDC coating has significant antibiotic properties and can effectively prevent colonization and growth of the bacteria. Therefore, when the endotracheal tube loaded with antimicrobial peptide MDC coating is applies to artificial tracheal intubation and ventilator, the occurrence of tracheal intubation ventilator-associated pneumonia can be decreased or delayed, the medical economic burden can be reduced, and the patient's physical and mental pain can be relieved. Thus, the prospect is vast.
Inventors:
LU XUEMEI (CN)
GUI SHUIQING (CN)
ZHANG LUN (CN)
JIN XIAOBAO (CN)
ZHU JIAYONG (CN)
GUI SHUIQING (CN)
ZHANG LUN (CN)
JIN XIAOBAO (CN)
ZHU JIAYONG (CN)
Application Number:
PCT/CN2018/083402
Publication Date:
July 25, 2019
Filing Date:
April 17, 2018
Export Citation:
Assignee:
UNIV GUANGDONG PHARM (CN)
International Classes:
A61L29/16; A61L29/08; C09D5/14
Foreign References:
| CN107459568A | 2017-12-12 | |||
| CN101428157A | 2009-05-13 | |||
| CN103948973A | 2014-07-30 | |||
| CN103933617A | 2014-07-23 |
Other References:
LU XUEMEI: "Cloning Expression and Antimicrobial Activities of Musca Domestica Cecropin Fused with Human Lysozyme", BASIC SCIENCES, CHINA MASTER'S THESES, no. 6, A006-102, 15 June 2011 (2011-06-15)
LU , X. M.: "Expression of the antimicrobial peptide cecropin fused with human lysozyme in Escherichia coli", APPL. MICROBIOL. BIOTECHNOL., 25 May 2010 (2010-05-25), pages 2169 - 2176, XP019841604
LU , X. ET AL.: "Bactericidal activity of Musca domestica cecropin (Mdc) on mu- ltidrug-resistant clinical isolate of Escherichia coli", APPL. MICROBIOL. BIOTECHNOL., vol. 95, no. 4, 28 December 2011 (2011-12-28), pages 939 - 945, XP035090905
DATABASE PROTEIN 18 December 2017 (2017-12-18), ANONYMOUS: "Cecropin-2 [Ceratitis capitata]", XP055625098, retrieved from NCBI Database accession no. XP_004534330
DATABASE PROTEIN 18 December 2017 (2017-12-18), ANONYMOUS: "Cecropin-2 [Ceratitis capitata]", XP055625106, retrieved from NCBI Database accession no. XP_004534333
DATABASE PROTEIN 18 December 2017 (2017-12-18), ANONYMOUS: "Cecropin-2-like [Ceratitis capitata]", XP055625109, retrieved from NCBI Database accession no. XP_004534331
DATABASE PROTEIN 5 October 2014 (2014-10-05), LU , X.: "HTPP-MDC fusion peptide, partial [synthetic construct)", XP055625115, retrieved from NCBI Database accession no. AIR95616
DATABASE NUCLEOTIDE 21 January 2007 (2007-01-21), JIN, X.B.: "Musca domestica cecropin precursor, mRNA, complete cds", XP055625117, Database accession no. EF175878
LU , X. M.: "Expression of the antimicrobial peptide cecropin fused with human lysozyme in Escherichia coli", APPL. MICROBIOL. BIOTECHNOL., 25 May 2010 (2010-05-25), pages 2169 - 2176, XP019841604
LU , X. ET AL.: "Bactericidal activity of Musca domestica cecropin (Mdc) on mu- ltidrug-resistant clinical isolate of Escherichia coli", APPL. MICROBIOL. BIOTECHNOL., vol. 95, no. 4, 28 December 2011 (2011-12-28), pages 939 - 945, XP035090905
DATABASE PROTEIN 18 December 2017 (2017-12-18), ANONYMOUS: "Cecropin-2 [Ceratitis capitata]", XP055625098, retrieved from NCBI Database accession no. XP_004534330
DATABASE PROTEIN 18 December 2017 (2017-12-18), ANONYMOUS: "Cecropin-2 [Ceratitis capitata]", XP055625106, retrieved from NCBI Database accession no. XP_004534333
DATABASE PROTEIN 18 December 2017 (2017-12-18), ANONYMOUS: "Cecropin-2-like [Ceratitis capitata]", XP055625109, retrieved from NCBI Database accession no. XP_004534331
DATABASE PROTEIN 5 October 2014 (2014-10-05), LU , X.: "HTPP-MDC fusion peptide, partial [synthetic construct)", XP055625115, retrieved from NCBI Database accession no. AIR95616
DATABASE NUCLEOTIDE 21 January 2007 (2007-01-21), JIN, X.B.: "Musca domestica cecropin precursor, mRNA, complete cds", XP055625117, Database accession no. EF175878
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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