Title:
ENGINEERED ANTIBODY FC VARIANTS
Document Type and Number:
WIPO Patent Application WO/2017/040380
Kind Code:
A3
Abstract:
In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for FcγRIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.γ
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Inventors:
GEORGIOU GEORGE (US)
LEE CHANG-HAN (US)
LEE CHANG-HAN (US)
Application Number:
PCT/US2016/049214
Publication Date:
April 20, 2017
Filing Date:
August 29, 2016
Export Citation:
Assignee:
RES DEV FOUNDATION (US)
International Classes:
C07K16/28; C07K16/00
Foreign References:
| US20130058919A1 | 2013-03-07 | |||
| EP2679681A1 | 2014-01-01 | |||
| US20150315284A1 | 2015-11-05 |
Other References:
F. MIMOTO ET AL: "Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131", PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 26, no. 10, 5 June 2013 (2013-06-05), pages 589 - 598, XP055087986, ISSN: 1741-0126, DOI: 10.1093/protein/gzt022
SANG TAEK JUNG ET AL: "Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High Fc[gamma]RIIa Affinity and Selectivity", ACS CHEMICAL BIOLOGY, vol. 8, no. 2, 15 February 2013 (2013-02-15), US, pages 368 - 375, XP055318855, ISSN: 1554-8929, DOI: 10.1021/cb300455f
JUNG SANG TAEK ET AL: "Aglycosylated IgG variants expressed in bacteria that selectively bind Fc gamma RI potentiate tumor cell killing by monocyte-dendritic cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 107, no. 2, 1 January 2010 (2010-01-01), pages 604 - 609, XP009143225, ISSN: 0027-8424, DOI: 10.1073/PNAS.0908590107
SANG TAEK JUNG ET AL: "Engineering an aglycosylated Fc variant for enhanced Fc[gamma]RI engagement and pH-dependent human FcRn binding", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 19, no. 5, 1 September 2014 (2014-09-01), KR, pages 780 - 789, XP055318860, ISSN: 1226-8372, DOI: 10.1007/s12257-013-0432-z
SANG TAEK JUNG ET AL: "Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High Fc[gamma]RIIa Affinity and Selectivity", ACS CHEMICAL BIOLOGY, vol. 8, no. 2, 15 February 2013 (2013-02-15), US, pages 368 - 375, XP055318855, ISSN: 1554-8929, DOI: 10.1021/cb300455f
JUNG SANG TAEK ET AL: "Aglycosylated IgG variants expressed in bacteria that selectively bind Fc gamma RI potentiate tumor cell killing by monocyte-dendritic cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 107, no. 2, 1 January 2010 (2010-01-01), pages 604 - 609, XP009143225, ISSN: 0027-8424, DOI: 10.1073/PNAS.0908590107
SANG TAEK JUNG ET AL: "Engineering an aglycosylated Fc variant for enhanced Fc[gamma]RI engagement and pH-dependent human FcRn binding", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 19, no. 5, 1 September 2014 (2014-09-01), KR, pages 780 - 789, XP055318860, ISSN: 1226-8372, DOI: 10.1007/s12257-013-0432-z
Attorney, Agent or Firm:
FINDLAY, Geoffrey, S. (US)
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