Title:
ENGINEERED CARDIAC TISSUES AND METHODS OF USING THEM
Document Type and Number:
WIPO Patent Application WO/2012/170490
Kind Code:
A3
Abstract:
Disclosed are engineered cardiac tissues. The tissues include cardiomyocyte cells derived from a pluripotent cell, fibroblast cells and extracellular matrix components. The growth ability of the fibroblast cells may be limited. The tissue contracts coherently or synchronously with electrical pacing by an external electrical stimulator. Methods of using the tissues described herein are also provided.
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Inventors:
WAKATSUKI TETSURO (US)
Application Number:
PCT/US2012/041048
Publication Date:
May 08, 2014
Filing Date:
June 06, 2012
Export Citation:
Assignee:
INVIVOSCIENCES LLC (US)
WAKATSUKI TETSURO (US)
WAKATSUKI TETSURO (US)
International Classes:
C12N5/02; A01N1/02; C12N5/071
Foreign References:
| US20090202977A1 | 2009-08-13 | |||
| US20090169521A1 | 2009-07-02 |
Other References:
GUO ET AL.: "Creation of Engineered Cardiac Tissue In Vitro From Mouse Embryonic Stem Cells.", CIRCULATION., vol. 113, no. 18, 2006, pages 2229 - 37
BOATENG ET AL.: "Inhibition of fibroblast proliferation in cardiac myocyte cultures by surface microtopography.", AM J PHYSIOL CELL PHYSIOL., vol. 285, no. 1, 2003, pages C171 - 82
PARKER ET AL.: "Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.", PHILOS TRANS R SOC LOND B BIOL SCI., vol. 362, no. 1484, 2007, pages 1267 - 79
GERECHT-NIR ET AL.: "Biophysical regulation during cardiac development and application to tissue engineering.", INT J DEV BIOL., vol. 50, no. 2-3, 2006, pages 233 - 43
ZIMMERMANN ET AL.: "Engineered heart tissue for regeneration of diseased hearts.", BIOMATERIALS, vol. 25, no. 9, 2004, pages 1639 - 47
BOATENG ET AL.: "Inhibition of fibroblast proliferation in cardiac myocyte cultures by surface microtopography.", AM J PHYSIOL CELL PHYSIOL., vol. 285, no. 1, 2003, pages C171 - 82
PARKER ET AL.: "Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.", PHILOS TRANS R SOC LOND B BIOL SCI., vol. 362, no. 1484, 2007, pages 1267 - 79
GERECHT-NIR ET AL.: "Biophysical regulation during cardiac development and application to tissue engineering.", INT J DEV BIOL., vol. 50, no. 2-3, 2006, pages 233 - 43
ZIMMERMANN ET AL.: "Engineered heart tissue for regeneration of diseased hearts.", BIOMATERIALS, vol. 25, no. 9, 2004, pages 1639 - 47
Attorney, Agent or Firm:
VANHEYNINGEN, Tambryn, K. et al. (Sceales Starke & Sawall, LLP,100 East Wisconsin Avenue,Suite 110, Milwaukee WI, US)
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