Title:
ENGINEERED IMMUNE CELL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/071811
Kind Code:
A1
Abstract:
The present invention relates to an engineered immune cell, which expresses a cell surface molecule that specifically recognizes an antigen, and expresses exogenous TSLP and optionally other exogenous cytokines. Further provided in the present invention is the use of the engineered immune cell in the treatment of cancers, infections or autoimmune diseases. Compared with traditional engineered immune cells, the engineered immune cell of the present invention has a significantly improved tumor-killing activity.
Inventors:
XING YUN (CN)
REN JIANGTAO (CN)
REN JIANGTAO (CN)
Application Number:
PCT/CN2022/125019
Publication Date:
May 04, 2023
Filing Date:
October 13, 2022
Export Citation:
Assignee:
BIOHENG THERAPEUTICS LTD (GB)
International Classes:
C12N5/078; A61K39/00; A61P35/00; A61P37/00; C12N5/10; C12N15/63
Domestic Patent References:
| WO2020216238A1 | 2020-10-29 |
Foreign References:
| CN111542595A | 2020-08-14 | |||
| CN112292147A | 2021-01-29 | |||
| CN108350070A | 2018-07-31 |
Other References:
TERRY‐ANN M. MILFORD; RUIJUN J. SU; OLIVIA L. FRANCIS; INEAVELY BAEZ; SHANNALEE R. MARTINEZ; JACQUELINE S. COATS; ABBY J. WELDON; : "TSLP or IL‐7 provide an IL‐7Rα signal that is critical for human B lymphopoiesis", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-VCH, HOBOKEN, USA, vol. 46, no. 9, 12 July 2016 (2016-07-12), Hoboken, USA, pages 2155 - 2161, XP071226904, ISSN: 0014-2980, DOI: 10.1002/eji.201646307
IVA MARKOVIC' ET AL.: "Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer", FRONTIERS IN IMMUNOLOGY, vol. 11, no. 1557, 21 July 2020 (2020-07-21), XP055721673, ISSN: 1664-3224, DOI: 10.3389/fimmu.2020.01557
IVA MARKOVIC' ET AL.: "Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer", FRONTIERS IN IMMUNOLOGY, vol. 11, no. 1557, 21 July 2020 (2020-07-21), XP055721673, ISSN: 1664-3224, DOI: 10.3389/fimmu.2020.01557
Attorney, Agent or Firm:
FOUNDIN INTELLECTUAL PROPERTY (CN)
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