Title:
ENGINEERED INVARIANT CHAIN MOLECULE FOR IMPROVED MHC CLASS I LOADING
Document Type and Number:
WIPO Patent Application WO/2015/189267
Kind Code:
A3
Abstract:
The present invention relates to peptides presented on the cell surface of cells in the MHC class I (MHC I) context in which the invariant chain has been engineered to favor loading of specific antigens and generate CD8+ T-cell activation
Inventors:
WÄLCHLI SEBASTIEN P (NO)
GREGERS TONE FREDSVIK (NO)
INDERBERG ELSE MARIT SUSO (NO)
GAUDERNACK GUSTAV (NO)
KVALHEIM GUNNAR (NO)
BAKKE ODDMUND (NO)
GREGERS TONE FREDSVIK (NO)
INDERBERG ELSE MARIT SUSO (NO)
GAUDERNACK GUSTAV (NO)
KVALHEIM GUNNAR (NO)
BAKKE ODDMUND (NO)
Application Number:
PCT/EP2015/062933
Publication Date:
February 04, 2016
Filing Date:
June 10, 2015
Export Citation:
Assignee:
UNI I OSLO (NO)
International Classes:
A61K39/00; C07K7/06; C07K14/495; C07K14/74
Domestic Patent References:
| WO1999064588A1 | 1999-12-16 |
Other References:
SÉBASTIEN WÄLCHLI ET AL: "Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 44, no. 3, 27 December 2013 (2013-12-27), pages 774 - 784, XP055205786, ISSN: 0014-2980, DOI: 10.1002/eji.201343671
AUDE BONEHILL ET AL: "Efficient Presentation of Known HLA Class II-restricted MAGE-A3 Epitopes by Dendritic Cells Electroporated with Messenger RNA Encoding an Invariant Chain with Genetic Exchange of Class II-associated Invariant Chain Peptide", CANCER RESEARCH, vol. 63, 1 September 2003 (2003-09-01), pages 5587 - 5594, XP055206256
JEROEN VAN BERGEN ET AL: "Superior Tumor Protection Induced by a Cellular Vaccine Carrying a Tumor- specific T Helper Epitope by Genetic Exchange of the Class II-associated Invariant Chain Peptide", CANCER RESEARCH, 15 November 2000 (2000-11-15), pages 6427 - 6433, XP055205989, Retrieved from the Internet [retrieved on 20150803]
J. VAN BERGEN ET AL: "Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 94, no. 14, 8 July 1997 (1997-07-08), pages 7499 - 7502, XP055205983, ISSN: 0027-8424, DOI: 10.1073/pnas.94.14.7499
AUDE BONEHILL ET AL: "Efficient Presentation of Known HLA Class II-restricted MAGE-A3 Epitopes by Dendritic Cells Electroporated with Messenger RNA Encoding an Invariant Chain with Genetic Exchange of Class II-associated Invariant Chain Peptide", CANCER RESEARCH, vol. 63, 1 September 2003 (2003-09-01), pages 5587 - 5594, XP055206256
JEROEN VAN BERGEN ET AL: "Superior Tumor Protection Induced by a Cellular Vaccine Carrying a Tumor- specific T Helper Epitope by Genetic Exchange of the Class II-associated Invariant Chain Peptide", CANCER RESEARCH, 15 November 2000 (2000-11-15), pages 6427 - 6433, XP055205989, Retrieved from the Internet
J. VAN BERGEN ET AL: "Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 94, no. 14, 8 July 1997 (1997-07-08), pages 7499 - 7502, XP055205983, ISSN: 0027-8424, DOI: 10.1073/pnas.94.14.7499
Attorney, Agent or Firm:
PLOUGMANN & VINGTOFT A/S (2300 Copenhagen S, DK)
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