Title:
ENGINEERED MICROORGANISMS WITH ENHANCED PROTEIN EXPRESSION AND SECRETION
Document Type and Number:
WIPO Patent Application WO/2023/215221
Kind Code:
A3
Abstract:
The present disclosure provides materials and methods related to the production of peptides and polypeptides from engineered microorganisms. In particular, the present disclosure provides compositions and methods for producing a genetically modified microorganism (e.g., yeast cell) with enhanced protein expression and/or secretion.
Inventors:
CROOK NATHAN (US)
DURMUSOGLU DENIZ (US)
AL'ABRI IBRAHIM (US)
DURMUSOGLU DENIZ (US)
AL'ABRI IBRAHIM (US)
Application Number:
PCT/US2023/020551
Publication Date:
December 28, 2023
Filing Date:
May 01, 2023
Export Citation:
Assignee:
UNIV NORTH CAROLINA STATE (US)
International Classes:
C12N1/16; C12N15/01; C12N15/11; C07K16/00
Domestic Patent References:
| WO2019070246A1 | 2019-04-11 |
Foreign References:
| US5679544A | 1997-10-21 | |||
| US20040029252A1 | 2004-02-12 |
Other References:
JENSEN EMIL D., DEICHMANN MARCUS, MA XIN, VILANDT RIKKE U., SCHIESARO GIOVANNI, ROJEK MARIE B., LENGGER BETTINA, ELIASSON LINE, VE: "Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts", BIORXIV, 12 January 2022 (2022-01-12), pages 1 - 44, XP093126551, Retrieved from the Internet [retrieved on 20240201], DOI: 10.1101/2022.01.11.475777
Attorney, Agent or Firm:
SCHLUETER, Peter J. (US)
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