Title:
ENGINEERED POLYMERASES WITH IMPROVED THERMAL STABILITY
Document Type and Number:
WIPO Patent Application WO/2023/240230
Kind Code:
A3
Abstract:
Provided herein are engineered variants of archaeal polymerases that exhibit exonuclease-minus activity, enhanced thermostability, enhanced incorporation of 3' modified nucleotides, improved uracil-tolerance and/or reduce sequence-specific errors in polymerase-catalyzed nucleotide binding and extension reactions relative to wild type polymerase enzymes. Also provided are uses of the engineered polymerases for forming complexed polymerases and forming binding complexes, and uses for conducting nucleic acid sequencing reactions.
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Inventors:
HENTSCHEL JENDRIK (US)
KLEIN MICHAEL (US)
AMBROSO MARK (US)
LOPEZ TYLER (US)
KELLINGER MATTHEW (US)
SAADE VIRGINIA (US)
ADHIKARY RAMKRISHNA (US)
KLEIN MICHAEL (US)
AMBROSO MARK (US)
LOPEZ TYLER (US)
KELLINGER MATTHEW (US)
SAADE VIRGINIA (US)
ADHIKARY RAMKRISHNA (US)
Application Number:
PCT/US2023/068193
Publication Date:
February 01, 2024
Filing Date:
June 09, 2023
Export Citation:
Assignee:
ELEMENT BIOSCIENCES INC (US)
International Classes:
C12N9/22; C12N15/52; C12N15/80
Foreign References:
| US20110104761A1 | 2011-05-05 | |||
| US20080280291A1 | 2008-11-13 | |||
| US20070141591A1 | 2007-06-21 |
Attorney, Agent or Firm:
SEQUEIRA, Antonia, L. et al. (US)
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