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Title:
ENGINEERED YEAST FOR PRODUCTION OF RENEWABLE CHEMICALS
Document Type and Number:
WIPO Patent Application WO/2013/173412
Kind Code:
A3
Abstract:
The present application relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial, renewable metabolites, e.g., isobutanol. In some embodiments, the recombinant yeast microorganisms may be engineered to comprise an isobutanol producing metabolic pathway, wherein said isobutanol producing metabolic pathway comprises at least one exogenous gene and/or at least one overexpressed endogenous gene encoding an enzyme that catalyzes a pathway step in the conversion of pyruvate to isobutanol. In certain exemplary embodiments, said recombinant yeast microorganisms may additionally or independently be engineered to alter the regulation, expression, and/or activity of a Mac1 pathway component.

Inventors:
DUNDON CATHERINE ASLESON (US)
HAWKINS ANDREW C (US)
ALBERT LYNNE (US)
SCHULTZ ANNE (US)
JANCAUSKAS JUSTAS (US)
ROBERG-PEREZ KEVIN (US)
Application Number:
PCT/US2013/041064
Publication Date:
March 13, 2014
Filing Date:
May 15, 2013
Export Citation:
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Assignee:
GEVO INC (US)
International Classes:
C12P7/16; C12N1/19; C12N9/04
Foreign References:
US20120028323A12012-02-02
US20130244243A12013-09-19
US20090075327A12009-03-19
Other References:
JUNGMANN, J ET AL.: "MAC1, A Nuclear Regulatory Protein Related To Cu-Dependent Transcription Factors Is Involved In Cu/Fe Utilization And Stress Resistance In Yeast.", EMBO J., vol. 12, no. 13, 15 December 1993 (1993-12-15), pages 5051 - 5056
ROMANO, G ET AL.: "Different Sets Of QTLs Influence Fitness Variation In Yeast", MOL SYST BIOL., vol. 6, 16 February 2010 (2010-02-16), pages 1 - 11
BOWMAN, S ET AL.: "The Nucleotide Sequence Of Saccharomyces cerevisiae Chromosome XIII.", NATURE, vol. 387, no. 6632 S, 29 May 1997 (1997-05-29), pages 90 - 93
Attorney, Agent or Firm:
BLINKA, Thomas A. et al. (1299 Pennsylvania Avenue N.W.,Suite 70, Washington District of Columbia, US)
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