ENGINEERING BACTERIA AND USE THEREOF IN PRODUCTION OF DANSHENSU

WIPO Patent Application WO/2019/200874

A1

Provided are a recombinant E. coli and the use thereof in the production of danshensu. The recombinant E. coli simultaneously expresses α-hydroxycarboxylic acid dehydrogenase, L-α-amino acid aminotransferase, and any one of glucose dehydrogenase, L-lactic dehydrogenase and L-glutamate dehydrogenase, and genes thereof involved in the decomposition of phenolic compounds are knocked out on the basis of host E. coli.

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CAI YUJIE (CN)
XIONG TIANZHEN (CN)
LIU JINBIN (CN)
DING YANRUI (CN)
BAI YAJUN (CN)
ZHENG XIAOHUI (CN)

PCT/CN2018/111895

October 24, 2019

October 25, 2018

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UNIV JIANGNAN (CN)

C12P7/42; C12N1/21; C12P13/06; C12R1/19

CN103667371A

2014-03-26

BAI, CHENLONG: "Constitutive Production of Salvianic Acid A in Escherichia Coli and Separation", MEDICINE AND HEALTH SCIENCES, THESIS, vol. 2017, no. 3, 15 March 2017 (2017-03-15), pages 12 - 34
ZHOU, LIANG: "Chromosome engineering of Escherichia coli for constitutive production of salvianic acid A", MICROBIAL CELL FACTORIES, vol. 16, no. 84, 16 May 2017 (2017-05-16), XP055647519, ISSN: 1475-2859

HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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