Title:
ENHANCED DIFFERENTIATION OF PANCREATIC ISLET CELLS
Document Type and Number:
WIPO Patent Application WO/2024/059776
Kind Code:
A3
Abstract:
Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
Inventors:
XIE CHUNHUI (US)
HARB GEORGE (US)
RYU ELIZABETH (US)
TECENO NICHOLAS (US)
FARRAR CHRISTOPHER (US)
CAREY BRYCE W (US)
HARB GEORGE (US)
RYU ELIZABETH (US)
TECENO NICHOLAS (US)
FARRAR CHRISTOPHER (US)
CAREY BRYCE W (US)
Application Number:
PCT/US2023/074279
Publication Date:
April 25, 2024
Filing Date:
September 15, 2023
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED (US)
International Classes:
C12N5/0735; A61K35/39; C12N5/071; C12N5/074
Attorney, Agent or Firm:
GROLZ, Edward (US)
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