ENHANCED PRODUCTIVITY BY ATTENUATION OF CHLOROPHYLL BINDING PROTEIN GENES

WIPO Patent Application WO/2017/070404

A3

Mutant photosynthetic algae having increased biomass productivity are provided. The mutants have attenuated expression of violaxanthin chlorophyll a binding proteins (VCP) or fucoxanthin chlorophyll a/c binding proteins (FCP), reduced chlorophyll, higher apparent ETR(II), little to no reduction in Pmax per cell, and decreased NPQ over a wide range of light intensities. Provided herein are constructs for attenuating or disrupting VCP or FCP genes. Also provided are methods of culturing VCP or FCP mutants for the production of biomass or other products.

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MEUSER JONATHAN E (US)
DIPETRILLO CHRISTEN G (US)
MCCARREN JAY (US)
BAILEY SHAUN (US)

PCT/US2016/058000

June 01, 2017

October 20, 2016

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SYNTHETIC GENOMICS INC (US)

C12Q1/68; C07H21/04; C12N1/13; C12N15/63; C12N15/74; C12N15/79; C12P7/40

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ZETSCHE ET AL.: "Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.", CELL, vol. 163, no. 3, 25 September 2015 (2015-09-25), pages 759 - 71, XP055267511

HAILE, Lisa, A. et al. (US)

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