ENHANCEMENT OF ABNORMAL TISSUE UPTAKE OF ANTIBODIES, TUMOR-SPECIFIC AGENTS OR CONJUGATES THEREOF FOR DIAGNOSTIC IMAGING OR THERAPY

Title:

ENHANCEMENT OF ABNORMAL TISSUE UPTAKE OF ANTIBODIES, TUMOR-SPECIFIC AGENTS OR CONJUGATES THEREOF FOR DIAGNOSTIC IMAGING OR THERAPY

Document Type and Number:

WIPO Patent Application WO1992019213

Kind Code:

A3

Abstract:

Biomodulators, in conjunction with antibodies, tumor-specific agents or conjugates thereof, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity.

Inventors:

BORN JERRY L (US)
ESHIMA DENNIS (US)
MANN PAUL L (US)
MATWIYOFF NICHOLAS A (US)
RHODES BUCK A (US)

Application Number:

PCT/US1992/003667

Publication Date:

February 04, 1993

Filing Date:

May 01, 1992

Export Citation:

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Assignee:

UNIV NEW MEXICO (US)

International Classes:

A61K47/48; A61K49/08; A61K51/08; A61K51/10; (IPC1-7): A61K/

Foreign References:

US5053386A	1991-10-01
US4970212A	1990-11-13
US4816462A	1989-03-28

Other References:

JOURNAL OF IMMUNOLOGICAL METHODS, Vol. 152, (1992), THAKUR et al., "Evaluation of Biological Response Modifiers in the Enchancement of Tumor Uptake of Technetium 99m labeled macromolecules", pp. 209-216.
MECHANISMS OF AGEING AND DEVELOPMENT, Vol. 44, (1988), MANN et al., "Cell Surface oligosaccharide...", pp. 17-33.

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