Title:
Enhancement of anti-tumor activity of SHP2 inhibitor pyrimidinone in combination with novel cancer medicines in cancers
Document Type and Number:
WIPO Patent Application WO/2021/149817
Kind Code:
A1
Abstract:
The present invention provides a combination drug for the treatment of a malignant tumor comprising 2-((1R,2R,4S)-2-amino-7-azabicyclo[2.2.1]heptan-7-yl)-5-(3,4-dichloro-2-methyl-2H-indazol-5-yl)-3-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one or a pharmaceutically acceptable salt thereof, and at least one additional compound having an antitumor effect or at least one pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising both the active ingredients.
Inventors:
HOSHINO TAKUYA (JP)
KOMIYA YU (JP)
NAKATSURU YOKO (JP)
WALLIS NICOLA GAIL (GB)
KOMIYA YU (JP)
NAKATSURU YOKO (JP)
WALLIS NICOLA GAIL (GB)
Application Number:
PCT/JP2021/002318
Publication Date:
July 29, 2021
Filing Date:
January 22, 2021
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
OTSUKA PHARMA CO LTD (JP)
OTSUKA PHARMA CO LTD (JP)
International Classes:
A61K31/519; A61K31/506; A61K39/395; A61K45/00; A61P35/00
Domestic Patent References:
| WO2016203404A1 | 2016-12-22 | |||
| WO2017156397A1 | 2017-09-14 | |||
| WO2019165073A1 | 2019-08-29 | |||
| WO2018193410A1 | 2018-10-25 | |||
| WO2020022323A1 | 2020-01-30 |
Other References:
JEFFREY T. BAGDANOFF, ZHOULIANG CHEN, MICHAEL ACKER, YING-NAN CHEN, HOMAN CHAN, MICHAEL DORE, BRANT FIRESTONE, MICHELLE FODOR, JOR: "Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 62, no. 4, 28 February 2019 (2019-02-28), pages 1781 - 1792, XP055590731, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01725
See also references of EP 4093406A4
See also references of EP 4093406A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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