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Patent Searching and Data


Title:
ENHANCEMENT OF THE EFFICACY OF DRUGS BY DEUTERATION
Document Type and Number:
WIPO Patent Application WO1995026325
Kind Code:
A3
Inventors:
FOSTER ROBERT R
LEWANCZUK RICHARD
CAILLE GILLES
Application Number:
CA9500154W
Publication Date:
December 14, 1995
Filing Date:
March 27, 1995
Export Citation:
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Assignee:
ISOTECHNIKA INC.
International Classes:
C07D215/56; A61K31/445; A61K31/451; A61P9/12; C07B59/00; C07C233/33; C07D211/90; C07D487/04; G01N33/15; (IPC1-7): C07B59/00
Domestic Patent References:
WO1989009486A11989-10-05
Foreign References:
FR2673291A11992-08-28
Other References:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.28, no.3, 1993, PARIS pages 259 - 263 D. RAMPE ET AL 'Deuterated analogs of verapamil and nifedipine. Synthesis and biological activity'
'Chemical Abstracts Tenth Collective Index, Chemical Substances' 1982 , AMERICAN CHEMICAL SOCIETY see page 46167CS, col. 1: C-14-, D- and N-15-labeled dihydropyridine derivatives
'Chemical Abstracts Eleventh Collective Index, Chemical Substances' 1987 , AMERICAN CHEMICAL SOCIETY see page 58923CS, col. 2: C-14-labeled dihydropyridine derivatives
'Chemical Abstracts Twelfth Collective Index, Chemical Substances' 1992 , AMERICAN CHEMICAL SOCIETY see page 79669CS, col. 2 to page 79670CS, col. 1: C-13-, C-14- and D-labeled dihydropyridine derivatives
INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART A: APPLIED RADIATION AND ISOTOPES, vol.42, no.9, 1991, OXFORD GB pages 871 - 875 S. STONE-ELANDER ET AL 'Synthesis of Äisopropyl-11CÜnimodipine for in vivo studies of dihydropyridine binding in man using positron emission tomography'
ANALYTICA CHIMICA ACTA, vol.247, no.2, 1 July 1991, AMSTERDAM pages 249 - 254 M. DESAGE ET AL 'Gas chromatography with mass spectrometry or isotope-ratio mass spectrometry in studying the geographical origin of heroin'
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol.87, no.15, 5 August 1965, WASHINGTON, DC US pages 3365 - 3371 P. BEAK ET AL 'The deuteration of some N-methyl-4-pyridones'
TETRAHEDRON, (INCL. TETRAHEDRON REPORTS), vol.34, no.15, 1978, OXFORD GB pages 2377 - 2383 T. J. VAN BERGEN ET AL 'Hydride transfer from 1,4-dihydropyridines to pyridinium salts. Assessment of structural and energetic factors with Hantzsch ester derived compounds'
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