ENKURIN AND USES THEREOF

WIPO Patent Application WO2003072749

A3

A novel protein, enkurin, that is preferentially expressed in sperm has been discovered. Enkurin binds to TRPCs including TRPC2-S, a protein encoded by TRPC2 that is not predicted to be a calcium channel subunit. The invention includes methods of identifying compounds that affect enkurin expression or activity, and are useful, e.g., for contraception and treatment of infertility.

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FLORMAN HARVEY (US)
JUNGNICKEL MELISSA (US)
SUTTON KEITH (US)

PCT/US2003/005920

May 27, 2004

February 25, 2003

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UNIV MASSACHUSETS (US)
FLORMAN HARVEY (US)
JUNGNICKEL MELISSA (US)
SUTTON KEITH (US)

C07K14/47; A61K38/00; (IPC1-7): G01N33/53

YILDIRIM ET AL., PROCEEDINGS OF THE NATIONAL ACADEMIC SCIENCE, vol. 100, 4 March 2003 (2003-03-04), pages 2220 - 2225, XP002975905
BRANN ET AL., JOURNAL OF NEUROCHEMISTRY, vol. 83, December 2002 (2002-12-01), pages 1452 - 1460, XP002975906
IVES ET AL., JOURNAL OF BACTERIOLOGY, vol. 172, no. 9, 1990, pages 4936 - 4944, XP002975907

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