Title:
ENTERIC CAPSULE
Document Type and Number:
WIPO Patent Application WO/2017/030072
Kind Code:
A1
Abstract:
By assuming the use of gelatin as a main base material of a capsule coating, provided is a capsule having excellent enteric properties.
The enteric capsule contains alkali-treated gelatin and carrageenan as base materials of a capsule coating. In the gastric (aqueous) environment, the alkali-treated gelatin that is positively (+) charged coexists with the carrageenan that is negatively (-) charged and amino (NH4
+) group in the gelatin reacts with sulfate (SO3
-) group in the carrageenan so that the capsule coating is insolubilized. Meanwhile, in the enteric (aqueous) environment, the alkali-treated gelatin that is negatively (-) charged coexists with the carrageenan that is also negatively (-) charged and amino (NH4
+) group in the gelatin repulses with sulfate (SO3
-) group in the carrageenan so that the capsule coating quickly disintegrates and dissolves.
Inventors:
FUKASAWA TAKAYUKI (JP)
KOYAMA KENICHI (JP)
SUZUKI TOMOYA (JP)
KOYAMA KENICHI (JP)
SUZUKI TOMOYA (JP)
Application Number:
PCT/JP2016/073617
Publication Date:
February 23, 2017
Filing Date:
August 10, 2016
Export Citation:
Assignee:
SUNSHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K47/36; A61K8/11; A61K8/64; A61K8/73; A61K9/48; A61K47/42
Domestic Patent References:
| WO2011048388A2 | 2011-04-28 | |||
| WO2013100013A1 | 2013-07-04 | |||
| WO2000024267A1 | 2000-05-04 | |||
| WO2015195989A1 | 2015-12-23 |
Foreign References:
| JPH07145082A | 1995-06-06 | |||
| JP2009196961A | 2009-09-03 | |||
| JPH1176369A | 1999-03-23 |
Other References:
See also references of EP 3338804A4
Attorney, Agent or Firm:
YOSHIKAWA Koji et al. (JP)
Download PDF: