Title:
ENTEROBACTERIACEAE BACTERIA EXHIBITING INCREASED L-CYSTEINE PRODUCING ABILITY
Document Type and Number:
WIPO Patent Application WO/2014/148377
Kind Code:
A1
Abstract:
Enterobacteriaceae bacteria modified in a matter such that O-acetylserine sulfhydrylase B activity declines, the enterobacteriaceae bacteria being characterized by being modified so as to have the C-terminal region of a thiosulfuric-acid-binding protein deleted therefrom, and in that the L-cysteine producing ability is increased when in the presence of a sulfate. Using this enterobacteriaceae bacteria makes it possible to inexpensively and efficiently produce L-cysteine.
Inventors:
OHTSU IWAO (JP)
NAKATANI TAKESHI (JP)
TAMAKOSHI AI (JP)
TAKAHASHI SAYO (JP)
TAKAGI HIROSHI (JP)
NAKATANI TAKESHI (JP)
TAMAKOSHI AI (JP)
TAKAHASHI SAYO (JP)
TAKAGI HIROSHI (JP)
Application Number:
PCT/JP2014/056872
Publication Date:
September 25, 2014
Filing Date:
March 14, 2014
Export Citation:
Assignee:
NAT UNIV CORP NARA INST (JP)
International Classes:
C12N1/20; C12P13/12
Domestic Patent References:
| WO2012137689A1 | 2012-10-11 | |||
| WO2009104731A1 | 2009-08-27 | |||
| WO2001027307A1 | 2001-04-19 |
Foreign References:
| JP2010207194A | 2010-09-24 | |||
| JP2005137369A | 2005-06-02 | |||
| JP2010193788A | 2010-09-09 | |||
| US6218168B1 | 2001-04-17 | |||
| US5972663A | 1999-10-26 | |||
| US6303383B1 | 2001-10-16 | |||
| JPH057491A | 1993-01-19 |
Other References:
NAKATANI T. ET AL.: "Enhancement of thioredoxin/ glutaredoxinmediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli.", MICROBIAL CELL FACTORIES, vol. 11, no. 62, 2012, pages 1 - 9, XP021129015
HRYNIEWICZ M. ET AL.: "Sulfate and Thiosulfate Transport in Escherichia coli K-12: Identification of a Gene Encoding a Novel Protein Involved in Thiosulfate Binding.", JOURNAL OF BACTERIOLOGY, vol. 172, no. 6, 1990, pages 3358 - 3366, XP055284496
SIRKO A. ET AL.: "Sulfate and Thiosulfate Transport in Escherichia coli K-12: Nucleotide Sequence and Expression of the cysTWAM Gene Cluster.", JOURNAL OF BACTERIOLOGY, vol. 172, no. 6, 1990, pages 3351 - 3357, XP008042789
NAKATANI ET AL.: "Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli", MICROBIAL CELL FACTORIES, vol. 11, 2012, pages 62, XP021129015, DOI: doi:10.1186/1475-2859-11-62
BACKMANN, B. J.: "Escherichia coli and Salmonella: Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
"Aminosan Hakko", 30 May 1986, GAKKAI SHUPPAN CENTER (LTD., pages: 77 - 100
HRYNIEWICZ M. ET AL.: "Sulfate and Thiosulfate Transport in Escherichia coli K-12: Identification of a Gene Encoding a Novel Protein Involved in Thiosulfate Binding.", JOURNAL OF BACTERIOLOGY, vol. 172, no. 6, 1990, pages 3358 - 3366, XP055284496
SIRKO A. ET AL.: "Sulfate and Thiosulfate Transport in Escherichia coli K-12: Nucleotide Sequence and Expression of the cysTWAM Gene Cluster.", JOURNAL OF BACTERIOLOGY, vol. 172, no. 6, 1990, pages 3351 - 3357, XP008042789
NAKATANI ET AL.: "Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli", MICROBIAL CELL FACTORIES, vol. 11, 2012, pages 62, XP021129015, DOI: doi:10.1186/1475-2859-11-62
BACKMANN, B. J.: "Escherichia coli and Salmonella: Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
"Aminosan Hakko", 30 May 1986, GAKKAI SHUPPAN CENTER (LTD., pages: 77 - 100
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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