Title:
ENTEROCOCCUS FAECALIS HAVING RESISTANCE TO CEPHALOSPORIN AND HIGH EXPRESSION OF SIRTUIN 2-LIKE PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/082220
Kind Code:
A1
Abstract:
Provided are an Enterococcus faecalis having resistance to cephalosporin and high expression of sirtuin 2-like protein and the use thereof. The Enterococcus faecalis EF23 having resistance to cephalosporin and high expression of Sir2-like protein is deposited in the Preservation Center of Wuhan University, China Center for Type Culture Collection under the deposit number of CCTCC NO: M 2018012, the deposit address being Luojiashan, Wuchang, Wuhan City, Hubei Province, and the deposit date being 8 January 2018. Through the experiment it has been found that the Enterococcus faecalis EF23 having resistance to cephalosporin and high expression of Sir2-like protein can enhance aerobic oxidation of glucose in cells, increase mitochondrial respiration, and regulate ATP energy metabolic pathways, thereby realizing the treatment of various metabolism-related diseases, such as cell senescence, mitochondrial dysfunction and metabolic syndrome.
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Inventors:
LI SHIYU (CN)
SUN HANXIAO (CN)
WANG JIAJIA (CN)
FEI ZHENGBIN (CN)
WANG YUZHE (CN)
XU ZHENRUI (CN)
SUN HANXIAO (CN)
WANG JIAJIA (CN)
FEI ZHENGBIN (CN)
WANG YUZHE (CN)
XU ZHENRUI (CN)
Application Number:
PCT/CN2018/111319
Publication Date:
April 30, 2020
Filing Date:
October 23, 2018
Export Citation:
Assignee:
LI SHIYU (CN)
International Classes:
C12N1/20; A23L33/135; A23L33/195; A61K35/744; A61P39/06
Foreign References:
| CN107254419A | 2017-10-17 | |||
| CN107173817A | 2017-09-19 | |||
| CN107325997A | 2017-11-07 | |||
| CN107227269A | 2017-10-03 | |||
| CN108576823A | 2018-09-28 | |||
| EP3318263A1 | 2018-05-09 | |||
| JP2008000121A | 2008-01-10 |
Other References:
NORTH, B. J. ET AL.: "Sirtuins: Sir2-related NAD-dependent protein deacetylases", GENOME BIOLOGY, vol. 5, no. 5, 5 April 2004 (2004-04-05), pages R37, XP021012895, DOI: 20190702150615Y
GUO, Q. ET AL.: "The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (σH) and FOXO3a in Bifidobacterium longum and HEK293T cell respectively", FREE RADICAL BIOLOGY AND MEDICINE, vol. 108, 12 May 2017 (2017-05-12), pages 929 - 939, XP055553706, DOI: 20190702144428Y
DIVYASHRI, G. ET AL.: "Probiotic attributes, antioxidant, anti-inflammatory and neuromodulatory effects of Enterococcus faecium CFR 3003: in vitro and in vivo evidence", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 64, 1 December 2015 (2015-12-01), pages 1527 - 1540, XP055707477, DOI: 20190702150807A
GUO, Q. ET AL.: "The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (σH) and FOXO3a in Bifidobacterium longum and HEK293T cell respectively", FREE RADICAL BIOLOGY AND MEDICINE, vol. 108, 12 May 2017 (2017-05-12), pages 929 - 939, XP055553706, DOI: 20190702144428Y
DIVYASHRI, G. ET AL.: "Probiotic attributes, antioxidant, anti-inflammatory and neuromodulatory effects of Enterococcus faecium CFR 3003: in vitro and in vivo evidence", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 64, 1 December 2015 (2015-12-01), pages 1527 - 1540, XP055707477, DOI: 20190702150807A
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