Title:
ENTEROCOCCUS LACTIS AGAINST COLORECTAL TUMOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/116283
Kind Code:
A1
Abstract:
Provided is an Enterococcus lactis with the deposit number of CCTCC NO: M20211220, which is deposited in the China Center for Type Culture Collection. The provided Enterococcus lactis of CCTCC NO: M20211220 can still ensure a survival rate of 77.60% after incubation for 3 h in an artificial gastric juice environment with a pH of 4.0. In a mouse MC38 model, the Enterococcus lactis has a significant effect in inhibiting tumor volume.
Inventors:
ZHU YONGLIANG (CN)
MU XIAOJING (CN)
LIU DAN (CN)
ZHU MENGMENG (CN)
MA MENGNAN (CN)
MU XIAOJING (CN)
LIU DAN (CN)
ZHU MENGMENG (CN)
MA MENGNAN (CN)
Application Number:
PCT/CN2022/132525
Publication Date:
June 29, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
SUZHOU PREC BIOTECH CO LTD (CN)
International Classes:
C12N1/20; A61K35/744; A61K45/06; A61P35/00; C07K14/195; C12N15/31; C12Q1/6886; G01N33/574; C12R1/01
Domestic Patent References:
| WO2021170138A1 | 2021-09-02 |
Foreign References:
| CN112618576A | 2021-04-09 | |||
| CN114107133A | 2022-03-01 | |||
| CN105733978A | 2016-07-06 | |||
| CN112063566A | 2020-12-11 |
Other References:
DATABASE NUCLEOTIDE ANONYMOUS : "Enterococcus faecium strain 7 16S ribosomal RNA gene, partial sequence", XP093074509, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Enterococcus faecium strain HK 16S ribosomal RNA gene, partial sequence", XP093074510, retrieved from NCBI
MANSON ABIGAIL L, VAN TYNE DARIA, STRAUB TIMOTHY J, CLOCK SARAH, CRUPAIN MICHAEL, RANGAN URVASHI, GILMORE MICHAEL S, EARL ASHLEE M: "Chicken Meat-Associated Enterococci: Influence of Agricultural Antibiotic Use and Connection to the Clinic", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 85, no. 22, 15 November 2019 (2019-11-15), US , XP093074511, ISSN: 0099-2240, DOI: 10.1128/AEM.01559-19
RYU HODON, HENSON MICHAEL, ELK MICHAEL, TOLEDO-HERNANDEZ CARLOS, GRIFFITH JOHN, BLACKWOOD DENENE, NOBLE RACHEL, GOURMELON MICHÈLE,: "Development of Quantitative PCR Assays Targeting the 16S rRNA Genes of Enterococcus spp. and Their Application to the Identification of Enterococcus Species in Environmental Samples", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 79, no. 1, 1 January 2013 (2013-01-01), US , pages 196 - 204, XP093074512, ISSN: 0099-2240, DOI: 10.1128/AEM.02802-12
DATABASE NUCLEOTIDE ANONYMOUS : "Enterococcus faecium strain HK 16S ribosomal RNA gene, partial sequence", XP093074510, retrieved from NCBI
MANSON ABIGAIL L, VAN TYNE DARIA, STRAUB TIMOTHY J, CLOCK SARAH, CRUPAIN MICHAEL, RANGAN URVASHI, GILMORE MICHAEL S, EARL ASHLEE M: "Chicken Meat-Associated Enterococci: Influence of Agricultural Antibiotic Use and Connection to the Clinic", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 85, no. 22, 15 November 2019 (2019-11-15), US , XP093074511, ISSN: 0099-2240, DOI: 10.1128/AEM.01559-19
RYU HODON, HENSON MICHAEL, ELK MICHAEL, TOLEDO-HERNANDEZ CARLOS, GRIFFITH JOHN, BLACKWOOD DENENE, NOBLE RACHEL, GOURMELON MICHÈLE,: "Development of Quantitative PCR Assays Targeting the 16S rRNA Genes of Enterococcus spp. and Their Application to the Identification of Enterococcus Species in Environmental Samples", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 79, no. 1, 1 January 2013 (2013-01-01), US , pages 196 - 204, XP093074512, ISSN: 0099-2240, DOI: 10.1128/AEM.02802-12
Attorney, Agent or Firm:
JJS INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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