ENTEROTOXIGENIC E. COLI FUSION PROTEIN VACCINES

Title:

ENTEROTOXIGENIC E. COLI FUSION PROTEIN VACCINES

Document Type and Number:

WIPO Patent Application WO/2011/044499

Kind Code:

A3

Abstract:

The disclosure relates to fusions of enterotoxigenic Escherichia coli (ETEC) polynucleotides and polypeptides. In one example, a toxiod heat-labile (LT) and heat-stable (STa) fusion is described. This fusion may include LT with a substituted amino acid at position (192), a linker, and STa with a substituted amino acid at positions (11, 12, 13, or 14). Further provided are vaccines containing the disclosed fusions. Example methods for administering to a subject the disclosed vaccines and using the fusions and vaccines to reduce or eliminate contamination of a food or water supply are additionally contemplated.

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Inventors:

ZHANG WEIPING (US)

Application Number:

PCT/US2010/052041

Publication Date:

August 18, 2011

Filing Date:

October 08, 2010

Export Citation:

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Assignee:

UNIV SOUTH DAKOTA (US)
ZHANG WEIPING (US)

International Classes:

A61K38/10; A61K31/195; A61K38/16; A61K38/46; A61K39/395; A61P31/00

Foreign References:

US6087109A	2000-07-11
US20080107653A1	2008-05-08
US4761372A	1988-08-02
US7527802B2	2009-05-05

Other References: