Title:
ENVENOMATION THERAPIES AND RELATED PHARMACEUTICAL COMPOSITIONS, SYSTEMS AND KITS
Document Type and Number:
WIPO Patent Application WO/2016/081826
Kind Code:
A3
Abstract:
The invention provides methods of treatment, pharmaceutical compositions, systems and kits appropriate for first line and/or adjunct therapy with antivenom using at least one active component, in some instances at least two active components and in other instances no more than two active components selected from the group consisting of a selective secretory PLA2 inhibitor (sPLA2 or PLA2 inhibitor), a metalloproteinase inhibitor, a serine protease inhibitor, antivenom, one or more acetylcholinesterase inhibitors or a nAChR agonist paired with a mAChR antagonist, a NMDA receptor antagonist and a spreading factor inhibitor to treat a subject who suffers from an envenomation, preferably at the time of envenomation and often within a period of less than about an hour after an envenomation or 6 hours after an envenomation and throughout the course of treatment at time with or without antivenom as an adjunct therapy after an envenomation by, for example, a snake or invertebrate.
Inventors:
LEWIN MATTHEW R (US)
Application Number:
PCT/US2015/061834
Publication Date:
July 14, 2016
Filing Date:
November 20, 2015
Export Citation:
Assignee:
OPHIREX INC (US)
International Classes:
A61K31/00; A61P39/02
Domestic Patent References:
| WO2014039920A1 | 2014-03-13 |
Foreign References:
| US20140087003A1 | 2014-03-27 |
Other References:
RUCAVADO A ET AL.: "Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation.", TOXICON., vol. 43, no. 4, 15 March 2004 (2004-03-15), pages 417 - 424, XP055445653
CLARK JD ET AL.: "Potential therapeutic uses of phospholipase A2 inhibitors.", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 7, 2004, pages 937 - 950, XP002405708, DOI: doi:10.1517/13543776.14.7.937
TRINH H H ET AL.: "Use of CROFAB® antivenin in the management of a very young pediatric copperhead envenomation.", THE JOURNAL OF EMERGENCY MEDICINE, vol. 29, no. 2, 2005, pages 159 - 162, XP027720791
CLARK JD ET AL.: "Potential therapeutic uses of phospholipase A2 inhibitors.", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 7, 2004, pages 937 - 950, XP002405708, DOI: doi:10.1517/13543776.14.7.937
TRINH H H ET AL.: "Use of CROFAB® antivenin in the management of a very young pediatric copperhead envenomation.", THE JOURNAL OF EMERGENCY MEDICINE, vol. 29, no. 2, 2005, pages 159 - 162, XP027720791
Attorney, Agent or Firm:
COLEMAN, Henry, D. (P.C.714 Colorado Avenu, Bridgeport CT, US)
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