ENZYMATIC AMMONOLYSIS PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR DPP IV INHIBITORS

Title:

ENZYMATIC AMMONOLYSIS PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR DPP IV INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2005/108594

Kind Code:

A1

Abstract:

An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.

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Inventors:

PATEL RAMESH N (US)
HANSON RONALD L (US)
GILL IQBAL (US)
BRZOZOWSKI DAVID B (US)
SKONEZNY PAUL M (US)
POLITINO MICHAEL (US)
CHEN JASON G (US)
MORIS-VARAS FRANCISCO (US)
WHITE BRENDA J (US)

Application Number:

PCT/US2005/015199

Publication Date:

November 17, 2005

Filing Date:

May 03, 2005

Export Citation:

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Assignee:

BRISTOL MYERS SQUIBB CO (US)
PATEL RAMESH N (US)
HANSON RONALD L (US)
GILL IQBAL (US)
BRZOZOWSKI DAVID B (US)
SKONEZNY PAUL M (US)
POLITINO MICHAEL (US)
CHEN JASON G (US)
MORIS-VARAS FRANCISCO (US)
WHITE BRENDA J (US)

International Classes:

C07D207/22; C07D209/52; C07K5/065; C11D3/00; C12P17/10; (IPC1-7): C12P17/10

Foreign References:

US6395767B2

2002-05-28

Attorney, Agent or Firm:

Rodney, Burton (P.O. Box 4000 Princeton, NJ, US)

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