Title:
ENZYMATIC PREPARATION OF CHIRAL INDOLE ESTERS
Document Type and Number:
WIPO Patent Application WO/2004/104205
Kind Code:
A2
Abstract:
The present invention relates to a process for preparing a chiral indole ester by enzymatic resolution using a lipase from Pseudomonas fluorescens as the catalyst for the enantioselective hydrolysis of an ester.
Inventors:
JOURNET MICHEL (US)
LARSEN ROBERT D (US)
SARRAF STELLA T (US)
SHAFIEE ALI (US)
TRUPPO MATTHEW D (US)
UPADHYAY VEENA (US)
LARSEN ROBERT D (US)
SARRAF STELLA T (US)
SHAFIEE ALI (US)
TRUPPO MATTHEW D (US)
UPADHYAY VEENA (US)
Application Number:
PCT/US2004/014832
Publication Date:
December 02, 2004
Filing Date:
May 12, 2004
Export Citation:
Assignee:
MERCK & CO INC (US)
JOURNET MICHEL (US)
LARSEN ROBERT D (US)
SARRAF STELLA T (US)
SHAFIEE ALI (US)
TRUPPO MATTHEW D (US)
UPADHYAY VEENA (US)
JOURNET MICHEL (US)
LARSEN ROBERT D (US)
SARRAF STELLA T (US)
SHAFIEE ALI (US)
TRUPPO MATTHEW D (US)
UPADHYAY VEENA (US)
International Classes:
C07D209/94; C12P17/10; C12P41/00; C12P; (IPC1-7): C12P/
Domestic Patent References:
| WO2004103970A1 | 2004-12-02 |
Foreign References:
| US20030158246A1 | 2003-08-21 |
Other References:
CAMPOS ET AL: 'Asymetric Synthesis of a Prostagladin D2 Receptor Antagonist.' J.ORG.CHEM. vol. 70, 2005, pages 268 - 274
Attorney, Agent or Firm:
MERCK & CO., INC. (Rahway, New Jersey, US)
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