Title:
ENZYMATIC PREPARATION TECHNIQUE FOR ACYL/AROYL COENZYME A
Document Type and Number:
WIPO Patent Application WO/2022/228297
Kind Code:
A1
Abstract:
Provided are a method for large-scale preparation of acyl/aroyl coenzyme A by an enzymatic method, i.e., using an acyltransferase to transfer acyl/aroyl from a cheap acyl/aroyl donor onto acyl/aroyl receptor coenzyme A, thereby achieving large-scale synthesis of acyl/aroyl coenzyme A, and a use of the method in the preparation of acyl/aroyl coenzyme A.
Inventors:
ZHU PING (CN)
ZHANG BOYONG (CN)
WANG HAO (CN)
GONG TING (CN)
CHEN TIANJIAO (CN)
CHEN JINGJING (CN)
YANG JINLING (CN)
ZHANG BOYONG (CN)
WANG HAO (CN)
GONG TING (CN)
CHEN TIANJIAO (CN)
CHEN JINGJING (CN)
YANG JINLING (CN)
Application Number:
PCT/CN2022/088416
Publication Date:
November 03, 2022
Filing Date:
April 22, 2022
Export Citation:
Assignee:
INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES (CN)
International Classes:
C12N9/10; C12P17/00
Domestic Patent References:
| WO2018107880A1 | 2018-06-21 |
Foreign References:
| CN107418938A | 2017-12-01 |
Other References:
王润玲 (WANG, RUNLING): "六、乙酰化反应 (Non-official translation: VI. Acetylation Reaction)", 药物化学 第3版 中国医药科技出版社 (NON-OFFICIAL TRANSLATION: MEDICINAL CHEMISTRY, 3RD EDITION, CHINA MEDICAL SCIENCE PRESS), 31 October 2014 (2014-10-31), XP009540524
ZHANG YU-NAN, CHEN TIAN-JIAO;ZHU PING: "Iterative saturation mutagenesis and active site analysis of 10-deacetylbaccatin Ⅲ-10-β-O-acetyltransferase", CHINESE MEDICINAL BIOTECHNOLOGY, ZHONGGUO YIYAO SHENGWU JISHU XIEHUI, CN, vol. 13, no. 6, 1 December 2018 (2018-12-01), CN , pages 481 - 487, XP055980861, ISSN: 1673-713X, DOI: 10.3969/j.issn.1673-713X.2018.06.001
SHUJIE CHENG, HUANG SHIJIE; GUO LIQIONG; HAN FEI; LIN JUNFANG: "Cloning and Sequence Analysis of 10-Deacetylbaccatin Ⅲ-10-O-Acetyl Transferase Gene from Taxus chinensis var. mairei", BIOTECHNOLOGY BULLETIN, no. 1, 26 January 2011 (2011-01-26), pages 107 - 112, XP055980864, ISSN: 1002-5464, DOI: 10.13560/j.cnki.biotech.bull.1985.2011.01.027
WALKER KEVIN ET AL: "Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 583 - 587, XP002175247, ISSN: 0027-8424, DOI: 10.1073/pnas.97.2.583
LI BING-JUAN, WANG HAO, GONG TING, CHEN JING-JING, CHEN TIAN-JIAO, YANG JIN-LING, ZHU PING: "Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 8, no. 1, 11 August 2017 (2017-08-11), UK, pages 15544 - 14, XP055980865, ISSN: 2041-1723, DOI: 10.1038/ncomms15544
ZHANG YU-NAN, CHEN TIAN-JIAO;ZHU PING: "Iterative saturation mutagenesis and active site analysis of 10-deacetylbaccatin Ⅲ-10-β-O-acetyltransferase", CHINESE MEDICINAL BIOTECHNOLOGY, ZHONGGUO YIYAO SHENGWU JISHU XIEHUI, CN, vol. 13, no. 6, 1 December 2018 (2018-12-01), CN , pages 481 - 487, XP055980861, ISSN: 1673-713X, DOI: 10.3969/j.issn.1673-713X.2018.06.001
SHUJIE CHENG, HUANG SHIJIE; GUO LIQIONG; HAN FEI; LIN JUNFANG: "Cloning and Sequence Analysis of 10-Deacetylbaccatin Ⅲ-10-O-Acetyl Transferase Gene from Taxus chinensis var. mairei", BIOTECHNOLOGY BULLETIN, no. 1, 26 January 2011 (2011-01-26), pages 107 - 112, XP055980864, ISSN: 1002-5464, DOI: 10.13560/j.cnki.biotech.bull.1985.2011.01.027
WALKER KEVIN ET AL: "Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 583 - 587, XP002175247, ISSN: 0027-8424, DOI: 10.1073/pnas.97.2.583
LI BING-JUAN, WANG HAO, GONG TING, CHEN JING-JING, CHEN TIAN-JIAO, YANG JIN-LING, ZHU PING: "Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 8, no. 1, 11 August 2017 (2017-08-11), UK, pages 15544 - 14, XP055980865, ISSN: 2041-1723, DOI: 10.1038/ncomms15544
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