Title:
ENZYME-LOGIC BIOSENSING
Document Type and Number:
WIPO Patent Application WO/2011/116151
Kind Code:
A3
Abstract:
Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme- biocatalyzed logic gates adapted to receive biomarker input signals and perform an enzyme- biocatalyzed reaction resembling a Boolean logic operation using the received biomarker input signals to generate an output signal of the enzyme-biocatalyzed reaction. A signal processing unit is connected to the network of enzyme-biocatalyzed logic gates. The signal processing unit processes the generated output signal of the enzyme-biocatalyzed reaction and generates a digital binary output having a value of zero or one. The generated digital binary output indicates a type of an injury.
Inventors:
WANG JOSEPH (US)
WINDMILLER JOSHUA RAY (US)
SANTHOSH PADMANABHAN (US)
CHUANG MIN-CHIEH (US)
KATZ EVGENY (US)
HALAMEK JAN (US)
BOCHAROVA VERA (US)
PITA MARCOS (ES)
PRIVMAN VLADIMIR (US)
WINDMILLER JOSHUA RAY (US)
SANTHOSH PADMANABHAN (US)
CHUANG MIN-CHIEH (US)
KATZ EVGENY (US)
HALAMEK JAN (US)
BOCHAROVA VERA (US)
PITA MARCOS (ES)
PRIVMAN VLADIMIR (US)
Application Number:
PCT/US2011/028747
Publication Date:
January 19, 2012
Filing Date:
March 16, 2011
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
UNIV CLARKSON (US)
WANG JOSEPH (US)
WINDMILLER JOSHUA RAY (US)
SANTHOSH PADMANABHAN (US)
CHUANG MIN-CHIEH (US)
KATZ EVGENY (US)
HALAMEK JAN (US)
BOCHAROVA VERA (US)
PITA MARCOS (ES)
PRIVMAN VLADIMIR (US)
UNIV CLARKSON (US)
WANG JOSEPH (US)
WINDMILLER JOSHUA RAY (US)
SANTHOSH PADMANABHAN (US)
CHUANG MIN-CHIEH (US)
KATZ EVGENY (US)
HALAMEK JAN (US)
BOCHAROVA VERA (US)
PITA MARCOS (ES)
PRIVMAN VLADIMIR (US)
International Classes:
C12Q1/26; C12Q1/48; G01N33/15; G01N33/50
Other References:
MANESH, K. M. ET AL.: "Enzyme logic gates for the digital analysis of physiological level upon injury.", BIOSENSORS AND BIOELECTRONICS, vol. 24, 2009, pages 3569 - 3574, XP026305652, DOI: doi:10.1016/j.bios.2009.05.019
PRIVMAN, M. ET AL.: "Switchable electrode controlled by enzyme logic network system: Approaching physiologically regulated bioelectronics.", J. AM. CHEM. SOC., vol. 131, no. 3, 2009, pages 1314 - 1321
ZHOU, J. ET AL.: "Enzyme-based NAND and NOR logic gates with modular design.", J. PHYS. CHEM. B, vol. 113, 2009, pages 16065 - 16070
ZHOU, J. ET AL.: "Bioelectrocatalytic system coupled with enzyme-based biocomputing ensembles performing boolean logic operations: Approaching "Smart" physiologically controlled biointerfaces.", ACS APPLIED MATERIALS & INTERFACES, vol. 1, no. 1, 2009, pages 144 - 149
PRIVMAN, M. ET AL.: "Switchable electrode controlled by enzyme logic network system: Approaching physiologically regulated bioelectronics.", J. AM. CHEM. SOC., vol. 131, no. 3, 2009, pages 1314 - 1321
ZHOU, J. ET AL.: "Enzyme-based NAND and NOR logic gates with modular design.", J. PHYS. CHEM. B, vol. 113, 2009, pages 16065 - 16070
ZHOU, J. ET AL.: "Bioelectrocatalytic system coupled with enzyme-based biocomputing ensembles performing boolean logic operations: Approaching "Smart" physiologically controlled biointerfaces.", ACS APPLIED MATERIALS & INTERFACES, vol. 1, no. 1, 2009, pages 144 - 149
Attorney, Agent or Firm:
LEE, Hwa, C. (P.O. Box 1247Seattle, WA, US)
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