Title:
ENZYME-MODIFIED ANTICOAGULANT VALVE AND MANUFACTURING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/135453
Kind Code:
A1
Abstract:
Provided are an enzyme-modified anticoagulant valve and a manufacturing method therefor. The manufacturing method is: (1) placing a bioprosthetic valve material in a mixture of a polyphenol compound and a soluble metal salt for a reaction, and cleaning the bioprosthetic valve material when the reaction is completed; (2) crosslinking the bioprosthetic valve material using glutaraldehyde; and (3) utilizing an enzyme solution to treat the crosslinked bioprosthetic valve material, where the enzyme in the enzyme solution is capable of utilizing glucose to produce hydrogen peroxide. The inherent characteristics of the valve are utilized to modify a polyphenol-metal conjugate and glucose oxidase, the requirement on the valve for in vivo long-acting anticoagulation is implemented simply and efficiently, and the failure rate of the valve is reduced.
Inventors:
YANG LI (CN)
WANG YUNBING (CN)
LUO RIFANG (CN)
WANG YUNBING (CN)
LUO RIFANG (CN)
Application Number:
PCT/CN2021/140377
Publication Date:
June 30, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
JILIN VENUS HAOYUE MEDICAL LTD (CN)
International Classes:
C12N9/04; A61L27/36; A61L33/02; A61L33/04; A61L33/16
Foreign References:
| CN104194460A | 2014-12-10 | |||
| CN110152066A | 2019-08-23 | |||
| CN109999008A | 2019-07-12 | |||
| CN112741930A | 2021-05-04 | |||
| CN111870693A | 2020-11-03 | |||
| CN108785748A | 2018-11-13 | |||
| CN111840564A | 2020-10-30 |
Other References:
PATNAIK, S.S. ET AL.: "Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics", ANNALS OF BIOMEDICAL ENGINEERING, vol. 47, no. 1, 8 October 2018 (2018-10-08), XP036664873, DOI: 10.1007/s10439-018-02145-5
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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